CAS: 5241-66-7; (R)-2-((Tert-Butoxycarbonyl)Amino)-4-(Methylthio)Butanoic Acid

该化合物是D-methionine受保护的衍生物,在氨基终点处有一个异丁氧碳基(Boc)组,该化合物在Peptide合成中广泛使用,该组作为氨基功能的临时保护组,能够在温酸条件下有选择地取消保护.甲基苯丙胺D配置有助于为药物研究准备非天然peptides和手动构件.Boc-D-Met-OH显示高纯度和稳定性,确保固相和溶液-peptide相联反应的可靠性能.它与标准的联结试剂的兼容性使它成为建造具有精确立体化学控制的复合石化结构的多用途中间体.

结构式图片

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93000-03-4 112883-40-6 1152-62-1

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CAS号348-67-4 D-蛋氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号91177-57-0 (R)-(1-羟基-4-(甲硫... | CAS号119975-64-3 啡肽 | CAS号26060-98-0 B°C-D-蛋氨酸N-羟基琥珀酰亚胺酯 | CAS号69612-71-1 B°C-D-Met-Gly-OH | CAS号82611-48-1 B°C-Freidinger′...

合成工艺路线路线简述

    📜D-蛋氨酸 反应生成 N-Boc-D-蛋氨酸
    参考文献:某些含硫二肽和缬氨酰缬氨酸的银(i)配合物的形成常数
    标题:某些含硫二肽和缬氨酰缬氨酸的银(i)配合物的形成常数
    摘要:已经确定了在25oc和i = 0.10 Mol Dm-3(kno 3)时的形成常数,其中包括具有九个二肽的ag I配合物,这些二肽结合了含有一个(糖基蛋氨酸和蛋氨酸基甘氨酸)或两个硫供体原子的侧链. .在从相同的氨基酸和不同手性的形成在后一种情况下二肽进行了研究(例如,大号-Methionyl-大号-甲硫氨酸和大号-Methionyl-D蛋氨酸).将结果与缬氨酰缬氨酸进行比较.形成常数的值根据二肽的优选构象和ag的趋势来解释i与s-供体原子键合或通过形成二聚体配合物进行线性配位.
    DOI:10.1039/dt9840002305

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-7659364-B2
    优先权日:2001-11-15
    标 题 :N-methyl-homocysteines and their use as well as process for their production
    发明人:WILLUHN MARC; PLATZEK JOHANNES; OTTOW ECKHARD; PETROV ORLIN; BORM CLAUDIA; HINZ DIRK; MANN GREGOR; LISTER-JAMES JOHN; WILSON DAVID M
    权利人:CIS BIO INT
    摘要:The synthesis of N-methyl-homocysteines and their use are described.

    专利号:US-3941763-A
    优先权日:1975-03-28
    标题:PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
    发明人:SARANTAKIS DIMITRIOS
    权利人:AMERICAN HOME PROD
    摘要:The synthesis of the decapeptide pGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 by solid-phase techniques is described. The decapeptide inhibits LH release.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1007/978-981-97-4596-8_17
    摘要:Tiwari VK, Jaiswal MK, Rajkhowa S, Singh SK. Intramolecular Click Chemistry in Organic Synthesis. 2024. In: Materials Horizons: From Nature to Nanomaterials.
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