专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-7659364-B2 优先权日:2001-11-15 标 题 :N-methyl-homocysteines and their use as well as process for their production 发明人:WILLUHN MARC; PLATZEK JOHANNES; OTTOW ECKHARD; PETROV ORLIN; BORM CLAUDIA; HINZ DIRK; MANN GREGOR; LISTER-JAMES JOHN; WILSON DAVID M 权利人:CIS BIO INT 摘要:The synthesis of N-methyl-homocysteines and their use are described.
专利号:US-3941763-A 优先权日:1975-03-28 标题:PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates 发明人:SARANTAKIS DIMITRIOS 权利人:AMERICAN HOME PROD 摘要:The synthesis of the decapeptide pGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 by solid-phase techniques is described. The decapeptide inhibits LH release.