CAS: 4605-14-5; N1,N1'-(Propane-1,3-Diyl)Bis(Propane-1,3-Diamine)

该化合物是一个多胺化合物,其结构上与精子相似,缺乏一种二胺乙烯单位;它是一种无色晶状固体,由于存在多种地雷群体,在水中可以溶解,并具有基本特性;诺斯佩雷在细胞过程,特别是在细胞生长和分化方面起着重要作用,并参与各种生物功能,包括细胞信号和核糖核酸的稳定;其多胺结构允许它与DNA和RNA互动,影响基因表达和细胞代谢;诺斯佩雷对药理研究,特别是其治疗癌症的潜在应用和细胞反应的调节器,引起了兴趣;然而,其生物影响可能取决于浓度,必须进一步研究,以充分了解其行动机制和潜在副作用.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号35514-00-2 N1,N3-bis(2-cya... | CAS号503-29-7 氮杂环丁烷 | CAS号56-18-8 3,3'-二氨基二丙胺 | CAS号477808-24-5 3,9-dioxo-4,8-d... | CAS号109-76-2 1,3-丙二胺 | CAS号129157-76-2 N1-(3-(azetidin... | CAS号109-64-8 1,3-二溴丙烷 | CAS号54262-75-8 1-氮杂丁烷丙胺 | CAS号110-95-2 四甲基丙二胺

合成工艺路线路线简述

  • 合成目标产物 N,N'-Bis(3-Aminopropyl)-1,3-Propanediamine 主要起始原料 Azetidine And Dipropylenetriamine
  • (文献来源)合成步骤主要原料 Azetidine 和 Dipropylenetriamine
📜N1,N3-Bis(2-Cyanoethyl)Propane-1,3-Diamine置于w-2 Raney Ni 氨,氢气体系中,用 甲醇 作为反应溶剂,化学反应 65.0H,以67%的收率获得产物n,N'-双(3-氨丙基)-1,3-丙二胺
参考文献:Dna结合和基因传递的聚胺-聚乙二醇构建体的合成和表征.
标题:Dna结合和基因传递的聚胺-聚乙二醇构建体的合成和表征.
摘要:需要改进的非病毒载体系统,以在基因治疗中有效地将dna传递至靶细胞核.通过适当的boc保护的嘧啶衍生物与ω-甲氧基peg环氧乙烷基甲基醚的反应合成了一系列线性多胺聚(乙二醇)(peg)构建体.通过这种方法已经制备了带有1-3个meopeg单元和0,2或4个n-甲基的构建体.h2N(ch2)3Nboc(ch2)3Nboc(ch2)3Nhboc是通过在一个锅中通过三氟乙酰基除草剂,Boc的连接以及去除三氟乙酰基而有效制备的.类似的过程得到h 2 N(ch 2)3 Nboc(ch 2)3 Nboc(ch 2)3 Nh 2.用1,3-二溴丙烷将bocmen(ch2)3Nhme烷基化,得到bocmen(ch2)3Nme(ch2)3Nme(ch2)3Nmeboc.氰基乙基化/还原序列扩展了h2N(ch2)3Nboc(ch2)3Nboc(ch2)3Nh2,得到h2N(ch2)3Nboc(ch2)3Nbo
DOI:10.1016/s0968-0896(00)00113-9

海关参考信息

专利信息


专利号:US-12303865-B2
优先权日:2022-10-10
标 题 :Aqueous manufacture of aminated MOF complexes
发明人:GOSSELIN AERI; GAMORAS JOEL H; HERM ZOEY ROSE; MCDONALD THOMAS M; WENZ GRAHAM B; ZHU LINA
权利人:MOSAIC MAT INC
摘要:This disclosure relates to a select class of porous adsorbent, metal-organic frameworks (MOFs) capable of adsorbing carbon dioxide, their manufacturing, applications, and methods of use. Specifically, this disclosure relates to the solvo(hydro)thermal synthesis of a family of metal-organic frameworks, and their subsequent processing and transformation into material forms suitable for use in acid gas separations. More specifically, this disclosure relates to the preparation and recovery of MOFs at multiple scales of production, demonstrating the suitability and robustness of the materials thus obtained by the disclosed synthetic route and post-synthetic manipulation employed to tailor the materials for use in a variety of commercial acid gas separation systems, with improved performances, recyclability, and reuse characteristics.

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2014057877-A1
优先权日:2002-12-18
标题:Therapeutic polyamine compositions and their synthesis
发明人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
权利人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2013102730-A1
优先权日:2010-04-02
标 题:Polyamine-containing polymers and methods of synthesis and use
发明人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

专利号:DE-102005032795-A1
优先权日:2005-07-14
标 题 :Synthesis of porous manganese oxides

专利号:WO-2007006585-A2
优先权日:2005-07-14
标 题:Synthesis of a porous and/or stratified structure manganese oxide

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Nair SK, Verma A, Thomas TJ, Chou TC, Gallo MA, Shirahata A, Thomas T. Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett. 2007 Jun 8;250(2):311-22. Epub 2006 Dec 20.
2: Gabrielson EW, Pegg AE, Casero RA Jr. The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin Cancer Res. 1999 Jul;5(7):1638-41.

合成参考文献


摘要:P. Teyssie, G. Anderegg and G. Schwarzenbach. Bull. Soc. Chim. Belg. 71, 177 (1962).
参考文献:10.1104/pp.106.080911
摘要:Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R. Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion. Plant Physiol. 2006 Aug;141(4):1519–32.
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