专利号:US-7294719-B2 优先权日:2004-10-26 标题 :Synthesis of amino acid, N-carboxyanhydrides 发明人:CARUBIA JOHN MICHAEL; WEAVER THOMAS MARK; PONNUSAMY ETTIGOUNDER 权利人:SIGMA ALDRICH CO 摘要:A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by passing a purge gas through the reaction mixture as a carbonylation reagent is reacting with an amino acid or a salt thereof. The N-carboxyanhydrides produced by this process have a relatively lower chloride impurity content, relatively higher yields can be achieved, and the N-carboxyanhydrides can be produced on a larger scale.
专利号:US-2006106229-A1 优先权日:2004-10-26 标题 :Synthesis of amino acid, N-carboxyanhydrides
专利号:JP-2008518032-A 优先权日:2004-10-26 标题 :Synthesis of amino acid N-carboxyanhydride
专利号:CA-2584311-C 优先权日:2004-10-26 标题:Synthesis of amino acid, n-carboxyanhydrides
专利号:WO-2006047703-A2 优先权日:2004-10-26 标 题:Synthesis of amino acid, n-carboxyanhydrides
专利号:EP-1809616-A2 优先权日:2004-10-26 标题 :Synthesis of amino acid, n-carboxyanhydrides