CAS: 36190-95-1; 3'-O-Methylorobol

上下游产品

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on homoeriodictyol orobol

📜高圣草酚置于nadph Disodium Salt,口服葡萄糖体系中,用 二甲基亚砜 用作溶剂,化学反应 72.0H,反应生成3'-O-甲基香豌豆苷元
参考文献:A Versatile Microbial System For Biosynthesis Of Novel Polyphenols With Altered Estrogen Receptor Binding Activity
标题:A Versatile Microbial System For Biosynthesis Of Novel Polyphenols With Altered Estrogen Receptor Binding Activity
摘要:Isoflavonoids Possess Enormous Potential For Human Health With Potential Impact On Heart Disease And Cancer,And Some Display Striking Affinities For Steroid Receptors. Synthesized Primarily By Legumes,Isoflavonoids Are Present In Low And Variable Abundance Within Complex Mixtures,Complicating Efforts To Assess Their Clinical Potential. To Satisfy The Need For Controlled,Efficient,And Flexible Biosynthesis Of Isoflavonoids,A Three-Enzyme System Has Been Constructed In Yeast That Can Convert Natural And Synthetic Flavanones Into Their Corresponding Isoflavones In Practical Quantities. Based On The Determination Of The Substrate Requirements Of Isoflavone Synthase,A Series Of Natural And Nonnatural Isoflavones Were Prepared And Their Binding Affinities For The Human Estrogen Receptors (Er Alpha And Er Beta) Were Determined. Structure Activity Relationships Are Suggested Based On Changes To Binding Affinities Related To Small Variations On The Isoflavone Structure.
Doi:10.1016/j.Chembiol.2010.03.010