CAS: 35834-26-5; Rosamicin

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CAS号102438-11-9 rosaramicin N-oxide | CAS号61486-91-7 12,13-de-epoxy-... | CAS号122825-80-3 rosaramicin 20-... | CAS号56689-42-0 de-epoxy rosamicin | CAS号61486-91-7 12,13-de-epoxy-...

📜(S)-2-((Benzyloxy)Methyl)Butan-1-Ol置于咪唑,N-甲基咪唑,二乙烯基砜,2,2'-联吡啶,Sodium Periodate,正丁基锂,硼烷铵络合物,Glucose-6-Phosphate Dehydrogenase,2,2,6,6-四甲基哌啶氧化物,Glucose-6-Phosphate,三丁基膦,Ruthenium(Iii) Chloride Trihydrate,Palladium 10% On Activated Carbon,Nicotinamide Adenine Dinucleotide Phosphate,氢氟酸,氢气,碘,三氟甲烷磺酸亚铜(I)苯联合体 (2:1),Sodium Hydride,Caesium Carbonate,二异丙胺,三苯基膦,Lithium Chloride体系中,用 四氢呋喃,四氯化碳,Aq. Phosphate Buffer,正己烷,二氯甲烷,水,二甲基亚砜,乙酸乙酯,N,N-二甲基甲酰胺,异丙醇,乙腈 作为反应溶剂,化学反应 170.0H,反应生成 蔷薇霉素
参考文献:通过后期聚酮化合物组装,剪裁和 C-H 功能化实现基于泰内酯的大环内酯抗生素的化学酶促总合成和结构多样化
标题:通过后期聚酮化合物组装,剪裁和 C-H 功能化实现基于泰内酯的大环内酯抗生素的化学酶促总合成和结构多样化
摘要:聚酮合酶 (Pks) 是一种强大的催化平台,能够影响多个碳-碳键形成反应和氧化态调整.我们探索了产生 16 元泰乐菌素大环的两个末端 Pks 模块的功能,将它们用作泰内酯化学酶法合成中的生物催化剂,并在随后的阐述中完成了 Juvenimicin,M-4365 和 Rosamicin 类的首次全合成通过后期多样化开发大环内酯类抗生素.采用合成化学来反应生成可被倒数第二个 Juveiv Pks 模块的 Juvenimicin (Juv) 酮合酶接受的 Tylactone 六酮链延长中间体.六酮化合物在体外通过两个完整的模块(juveiv 和 Juvev)进行处理,其催化两个酮化合物单元的延伸和官能化,然后将所得八酮化合物环化成丁内酯.大环内酯化后,结合体内糖基化,选择性体外细胞色素 P450 介导的氧化和化学氧化,以少至 15 个线性步骤(总共 21 个)完成一系列大环内酯天然产物的可扩展构建.产率为
DOI:10.1021/jacs.7B02875

专利信息

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:US-6667406-B1
优先权日:1999-03-10
标题 :Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries
发明人：SUN SENGEN; MURRAY WILLIAM V
权利人:ORTHO MCNEIL PHARM INC
摘要:Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels Alder reaction. The invention is further directed to methods for synthesizing the libraries on solid supports. The invention is further directed to methods for identifying and isolating such hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds with useful and diverse activities from such libraries.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-9868747-B2
优先权日:2014-02-18
标题:Marinopyrrole derivatives and methods of making and using same
发明人：LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.