CAS: 2268-15-7; 2,3,5-Trifluorophenol

该化合物是一种氟化酚化合物,其特点是在苯环的2,3和5个位置有三种氟替代物.这一结构特征增强了其电子拖线特性,使其成为有机合成中有价值的中间体,特别是在制药和农用化学应用中.氟化物原子有助于提高稳定性,亲脂性和反应性,促进其在交叉反应中的使用,并成为更复杂的氟化分子的建筑块.其高纯度和一贯质量确保其在高要求的合成工艺中可靠性能.该化合物由于具有再活动性,通常在受控制的条件下处理,应储存在冷干的环境中.

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CAS号363-80-4 2,3,5-三氟苯胺 | CAS号2367-82-0 1,2,3,5-四氟苯 | CAS号182756-63-4 (2S)-2-amino-3-...

合成工艺路线路线简述

    📜1,2,3,5-四氟苯置于氢氧化钾体系中,用 二甲基亚砜 用作溶剂,化学反应 4.0H,反应生成2,3,5-三氟苯酚
    参考文献:Allen,Kim J.; Bolton,Roger; Williams,Gareth H.,Journal Of The Chemical Society. Perkin Transactions Ii,1983,P. 691-696
    标题:Allen,Kim J.; Bolton,Roger; Williams,Gareth H.,Journal Of The Chemical Society. Perkin Transactions Ii,1983,P. 691-696

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-6689919-B1
    优先权日:1999-09-22
    标 题 :Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative
    发明人:TSUCHIDA EISHUN; OYAIZU KENICHI; KUMAKI YOSUKE; SAITO KEI
    权利人:JAPAN SCIENCE & TECH CORP
    摘要:The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of -1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.

    专利号:EP-1695964-A1
    优先权日:2000-11-15
    标题 :Quinoline derivatives for use as intermediates in the synthesis of heterocyclylalcoyl piperidines

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    合成参考文献


    摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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