CAS: 1724-17-0; Methyl (4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylate

上下游产品

oleanolic acid methyl iodide methanol methyl 3-oxooleanolate3-Oxoolean-12-en-28-saeure-methylester methyl 3-oxooleanolate (4aS,6aS,6bR,10S,12aR)-methyl 10-acetoxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate 3β-benzoyloxy-oleanen-(12)-oic acid-(28)-methyl ester

📜Methyl (4As,6As,6Br,8Ar,10R,11R,12Ar,12Br,14Bs)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-11-(((Methylthio)Carbonothioyl)Oxy)-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-octadecahydropicene-4A(2H)-Carboxylate置于偶氮二异丁腈,三丁基氧化锡体系中,用 甲苯 用作溶剂,化学反应 3.0H,以85%的收率获得齐墩果酸甲酯
参考文献:Different Pathways For The Deoxygenation Of The A-Ring Of Natural Triterpene Compounds
标题:Different Pathways For The Deoxygenation Of The A-Ring Of Natural Triterpene Compounds
摘要:Some Deoxygenation Pathways Were Tested To Remove The Hydroxyl Groups Of The Natural Triterpenes Oleanolic Acid And Maslinic Acid To Obtain A Practical Starting Material For The Semisynthesis Of Other Interesting Organic Synthons. Different Deoxygenation Processes Were Carried Out Starting From These Triterpenic Acids Or From Several Derivatives Such As Methyl Esters And Epoxy Derivatives. The Hydroxyl Groups Were Transformed Into Some Intermediate Compounds Including Xanthyl,Thiocarbonyl Or Tosyl Derivatives. The Opening Of The Oxirane Ring Between C-2 And C-3 Was Also Achieved Through Different Methods Using Deoxygenating Reagents Such As Me3Sicl/nai,Wcl4/n-Buli And Cp2Ticl.
Doi:10.1080/14786410903172098

专利信息

专利号:CN-106632576-A
优先权日:2016-12-16
标题 :Improved Synthesis of 2-cyano-3,12-dioxooleanane-1,9(11)-diene-28-carboxylic acid