CAS: 157893-14-6; 3-Bromo-5-Methoxybenzoic Acid

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📜2-氨基-3-甲氧基苯甲酸置于盐酸,N-溴代丁二酰亚胺(Nbs),Sodium Nitrite体系中,用 四氢呋喃,甲醇,水 用作溶剂,化学反应 34.0H,反应生成3-溴-5-甲氧基苯甲酸
参考文献:Covalent Inhibitors Of Kras G12C
标题:Covalent Inhibitors Of Kras G12C
摘要:G12C突变k-Ras蛋白的不可逆抑制剂已提供.还公开了调节g12C突变k-Ras蛋白活性的方法以及通过g12C突变k-Ras蛋白介导的疾病治疗方法.

专利信息

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:WO-2024159285-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting aryl pyridine compounds. More specifically, the present invention relates to aryl pyridines comprising formula (I): (I), in which the substituents R1 to R10 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related diseases.