CAS: 1575-74-2; 2-Methylpent-4-Enoic Acid

相似化合物

99-67-2 16386-93-9 53399-81-8

上下游产品

CAS号106-95-6 烯丙基溴 | CAS号107-18-6 烯丙醇 | CAS号115-80-0 原丙酸三乙酯 | CAS号53399-81-8 2-甲基-4-戊烯酸乙酯 | CAS号35466-83-2 烯丙基甲基碳酸酯 | CAS号5281-63-0 methyl-2-propen... | CAS号53651-72-2 2-Allyl-2-Methy... | CAS号1823-54-7 3-甲基氧杂-2-酮 | CAS号1826-67-1 乙烯基溴化镁 | CAS号53399-81-8 2-甲基-4-戊烯酸乙酯 | CAS号33982-85-3 1-(2,3-二氢-1H-茚-... | CAS号20459-96-5 methyl 2-methyl... | CAS号201357-65-5 N-benzyl-2-meth... | CAS号2177-77-7 2-甲基戊酸甲酯 | CAS号26118-97-8 6-Hepten-3-one,... | CAS号88001-64-3 8-[tert-butyl(d... | CAS号88431-03-2 N,N,2-trimethyl... | CAS号89609-42-7 3-methyl-5-meth... | CAS号5187-71-3 2-甲基-4-戊醛

2-Allyl-2-Methylmalonic Acid 160.0 °C,2.67 Kpa 条件下,反应生成2-甲基-4-戊酸
参考文献:Synthesis Of S-(+)-4-Methyl-3-Heptanone,The Principal Alarm Pheromone Of Atta Texana,And Its Enantiomer
标题:Synthesis Of S-(+)-4-Methyl-3-Heptanone,The Principal Alarm Pheromone Of Atta Texana,And Its Enantiomer
摘要:
Doi:10.1016/s0040-4020(01)97286-2

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-6835849-B2
优先权日:2002-07-15
标题:Synthesis of alkenoate esters from lactones and alcohols
发明人：MANZER LEO ERNEST
权利人:DU PONT
摘要:The invention relates to the synthesis of alkenoate esters from a corresponding lactone and an alcohol in the presence of a basic catalyst. More specifically, this invention relates to the synthesis of methyl-4-pentenoate ester from 5-methyl butyrolactone and methanol.

专利号:WO-2012089181-A1
优先权日:2010-12-30
标题 :O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
发明人：VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
权利人:ZENTIVA KS; VLASAKOVA RUZENA; HAJICEK JOSEF; ZEZULA JOSEF
摘要:The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general formula II, in step A, are reacted in an inert organic solvent with an activating agent, optionally in presence of a catalyst or a base; in step B, the obtained compounds of general formula V, wherein R has the above mentioned meaning and X stands for chlorine or alkoxycarbonyloxyl group O-CO-OR 1 or pivaloyloxyl O-CO-t-Bu group, wherein R 1 is methyl or ethyl, are reacted with dimethylamine or its salts optionally in presence of a base; in step C, the obtained N, N-dimethylamides of general formula VI, wherein R has the above mentioned meaning, are reduced by means of hydride agents in a suitable solvent; in step D, the produced alkeneamines of general formula VII, wherein R has the above mentioned meaning, are hydrogenated on a metal catalysts in a suitable solvent; and, finally, in step E, the produced alkaneamines of general formula VIII, wherein R has the above mentioned meaning, are O-dealkylated by means of dealkylating agents, and, if required, the obtained tapentadol is converted by the action of a pharmaceutically acceptable acid to respective salts, e.g. hydrochloride.

专利号:US-2004059152-A1
优先权日:2002-07-15
标 题 :Synthesis of alkenoate esters from lactones and alcohols

专利号:WO-0212534-A2
优先权日:2000-08-09
标题 :Bio-intermediates for use in the chemical synthesis of polyketides

专利号:CA-2417358-A1
优先权日:2000-08-09
标题 :Bio-intermediates for use in the chemical synthesis of polyketides