CAS: 13725-33-2; 1H-Indole-5-Sulfonic Acid, 2-(1,3-Dihydro-3-Oxo-5-Sulfo-2H-Indol-2-Ylidene)-2,3-Dihydro-3-Oxo-, Potassium Salt (1:2)

该化合物是一种合成染料和以其充满活力的蓝色为特征的异丁二醇衍生物,是一种水溶性化合物,适合各种应用,特别是在纺织品中,以及食品和化妆品中的色素.该化合物的构造提高了其溶性,在水溶液中具有稳定性.已知该化合物的光敏度和耐退性,是染料应用中可取的特性.此外,该化合物经常在分析化学中用作试剂,因为其能够与某些金属离子形成复合体.安全数据表明,虽然一般认为该化合物具有低毒性,但应当遵守适当的处理和安全措施以避免潜在刺激.

结构式图片

合成工艺路线路线简述

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    专利信息


    专利号:WO-2024097977-A1
    优先权日:2022-11-04
    标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery
    发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S
    权利人:TUFTS COLLEGE
    摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.

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