CAS: 13250-12-9; (R)-(-)-2-Aminobutane

上下游产品

CAS号33966-50-6 丁胺 | CAS号113-24-6 丙酮酸钠 | CAS号108-05-4 乙酸乙烯酯 | CAS号108-22-5 醋酸异丙烯酯 | CAS号78-93-3 甲乙酮 | CAS号141-78-6 乙酸乙酯 | CAS号72-19-5 L-苏氨酸 | CAS号513-49-5 (S)-(+)-2-氨基丁烷 | CAS号37143-54-7 1-甲氧基-2-丙胺 | CAS号78-93-3 甲乙酮 | CAS号459856-18-9 Pexacerfont

仲丁胺置于磷酸吡哆醛,ω-Transaminase From Thermomicrobium Roseum,Piruvate体系中,用 Aq. Buffer 用作溶剂,化学反应 12.0H,以25.2%的收率获得(R)-(-)-仲丁胺
参考文献:新型高温稳定ω-转氨酶的鉴定及其在高温下手性胺的酶促合成中的应用†
标题:新型高温稳定ω-转氨酶的鉴定及其在高温下手性胺的酶促合成中的应用†
摘要:从a新的热稳定ω转氨酶thermomicrobium玫瑰色其显示广泛的底物特异性和高对映选择性鉴定,表达和生化表征.通过在高温下进行不对称合成和动力学拆分,证明了这种酶去除挥发性抑制副产物的优势.
Doi:10.1039/c6Ra15110H

专利信息

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.

专利号:US-5300437-A
优先权日:1989-06-22
标 题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; MATCHAM GEORGE W; ZEITLIN ANDREW L
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.

专利号:US-5169780-A
优先权日:1989-06-22
标题:Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W; ROZZELL JR JAMES D
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

专利号:US-4950606-A
优先权日:1989-06-22
标题 :Enantiomeric enrichment and stereoselective synthesis of chiral amines
发明人：STIRLING DAVID I; ZEITLIN ANDREW L; MATCHAM GEORGE W
权利人:CELGENE CORP
摘要:Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.