CAS: 1227595-72-3; 5-Chloro-6-(Trifluoromethyl)Pyridin-2-Amine

相似化合物

886762-09-0 1805474-71-8 1804660-54-5

上下游产品

2-氨基-6-(三氟甲基)吡啶 2-Amino-6-(Trifluoromethyl)Pyridine 34486-24-3

2-氨基-6-(三氟甲基)吡啶置于n-氯代丁二酰亚胺,高氯酸体系中,用 N,N-二甲基甲酰胺 用作溶剂,以62%的收率获得5-氯-6-三氟甲基吡啶-2-胺
参考文献:吡啶烟酰胺类衍生物,其制备方法及其在医药上的应用
标题:吡啶烟酰胺类衍生物,其制备方法及其在医药上的应用
摘要:本公开涉及吡啶烟酰胺类衍生物,其制备方法及其在医药上的应用.具体而言,本公开涉及一种通式(I)所示的吡啶烟酰胺类衍生物,其制备方法及含有该衍生物的药物组合物以及其作为治疗剂特别是作为nav1.8抑制剂的用途和其在制备治疗和/或减轻疼痛和疼痛相关疾病的药物中的用途.其中通式(I)的各取代基与说明书中的定义相同.

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.