CAS: 107099-99-0; (2,5-Dimethoxyphenyl)Boronic Acid

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1073339-07-7 1072952-43-2 957065-85-9

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CAS号121-43-7 硼酸三甲酯 | CAS号25245-34-5 2,5-二甲氧基溴苯 | CAS号150-78-7 对苯二甲醚 | CAS号5419-55-6 硼酸三异丙酯 | CAS号688-74-4 硼酸三丁酯 | CAS号7732-18-5 水 | CAS号39175-16-1 lithium,1,4-dim... | CAS号5312-97-0 2,5-二甲氧基苯甲腈 | CAS号43037-60-1 2-benzyl-1,4-di... | CAS号76246-92-9 1-(2,5-dimethox... | CAS号84355-10-2 1,4-dimethoxy-2... | CAS号39868-14-9 1-(2,5-dimethox...

对苯二甲醚置于正丁基锂,硼酸三异丙酯体系中,用 乙醚,正己烷 用作溶剂,化学反应 1.5H,以72%的收率获得2,5-二甲氧基苯硼酸
参考文献:6-芳基取代的三(2-吡啶基甲基)胺过渡金属配合物的结构和性质
标题:6-芳基取代的三(2-吡啶基甲基)胺过渡金属配合物的结构和性质
摘要:制备了一系列的[6-(2',5'-二甲氧基苯基)-2-吡啶基甲基]双(2-吡啶基甲基)胺(l)的金属(II)配合物.已确定l的x射线晶体结构及其mn,Fe,Co,Ni,Cu和zn的金属氯化物(II)配合物,并将结果进行了比较.还描述了不寻常的碳原子桥接的铜四聚体[cu 4(l)4(co 3)2 ] [bf 4 ] 4 .5.2H 2 O的制备和晶体结构.配合物的溶液状态结构由其物理化学和光谱性质推导得出.Zn(II)配合物[zncl 2(l)],表示关于 配体 NMR时标上的胺基团-提出了可变温度NMR研究的结果,并可以估算对 胺反转为56+/-0.5 Kj Mol-1.总体而言,发现通过单个6-芳基取代三(2-吡啶基甲基)胺(tpa)骨架而引入的分子内空间相互作用会导致所得金属配合物的结构和性质发生重大变化:特别是l中的芳基取代会导致(i)弱配体场相比,Tpa倾向于高自旋配合物,(II)配
Doi:10.1039/b207406K

专利信息

专利号:US-10947203-B2
优先权日:2016-03-25
标题 :1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
发明人：CHEN TAOSHENG; LIN WENWEI; WANG YUEMING
权利人:ST JUDE CHILDRENS RES HOSPITAL; ST JUDE CHILDRENS RSEARCH HOSPITAL
摘要:In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles having a structure represented by a formula: n nwhich are modulators the pregnane X receptor (“PXRâ€?); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-6872745-B2
优先权日:2000-04-14
标 题 :Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：JOHNSON JR THEODORE O; HUA YE; LUU HIEP T; DRAGOVICH PETER S
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.