CAS: 1068-55-9; Isopropylmagnesium Chloride

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CAS号75-29-6 2-氯丙烷 | CAS号90965-06-3 (1-重氮基-2-氧代丙基)膦酸二甲酯 | CAS号7439-95-4 镁标准溶液 | CAS号2027-17-0 2-异丙基萘 | CAS号107574-57-2 2-methyl-1-naph... | CAS号105652-41-3 N,N-diethyl-2-m... | CAS号108168-72-5 3-propan-2-ylcy... | CAS号565-69-5 2-甲基-3-戊酮 | CAS号34857-28-8 (S)-2-甲基-1-苯基丙-1-醇 | CAS号100-51-6 苯甲醇 | CAS号14898-86-3 R-(+)-2-甲基-1-苯基-1-丙醇 | CAS号5431-44-7 2,6-吡啶二甲醛 | CAS号34160-40-2 6-溴吡啶-2-甲醛

2-氯丙烷置于magnesium体系中,用 氘代四氢呋喃 用作溶剂,80.0 °C,689.49 Kpa 条件下,以95%的收率获得异丙基氯化镁
参考文献:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
标题:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
摘要:镁有机金属试剂在有机合成中占据中心位置.这些化合物的新鲜度是实现高转化率和可再现结果的关键.由金属镁合成格氏试剂的常用方法存在安全性问题,并且批次间存在差异.固体试剂与溶液相试剂相结合的管状反应器可实现有机镁试剂的连续流制备.据报道,使用镁金属和氯化锂的分层填充床柱来合成高浓度涡轮格氏试剂.一种低成本的吊舱式合成器原型,其中包括一次性使用的预包装全氟化药筒和试剂袋,用于按需实验室规模自动合成碳,氮,并介绍了氧涡轮镁碱.该概念将使人们能够以发现规模获得新鲜的有机镁试剂,并且与操作者在流动和/或有机金属化学领域的经验无关.
Doi:10.3762/bjoc.16.115

专利信息

专利号:US-11661406-B2
优先权日:2018-08-13
标 题 :Method for producing intermediate useful for synthesis of SGLT inhibitor
发明人：LI QING RI; YOON HEE KYOON
权利人:DAEWOONG PHARMACEUTICAL CO LTD
摘要:A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

专利号:US-8859763-B1
优先权日:2013-05-17
标题 :Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：VAYSSE-LUDOT LUCILE; LE FLOHIC ALEXANDRE; VAULTIER MICHEL; PUCHEAULT MATHIEU; KAMINSKI THOMAS
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:WO-2023126968-A1
优先权日:2021-12-29
标 题 :A process for the synthesis of bcx-1777 and bcx-4430
发明人：LANKALAPALLI RAVI SHANKAR; KARUNAKARAN ANITHA KRISHNAKUMAR; SURESH SANJAY VARMA; VELICKAKATHU OMANAKUTTAN YADHUKRISHNAN; KAPIYA SANGEETH; VALAPPIL SHIHAS AHAMMED CHEKRAIN; BERNARD PRABHA; THANGARASU ARUN KUMAR; DODDRAMAPPA DODDAMANI SHRIDEVI; JOHN JUBI; KOKKUVAYIL VASU RADHAKRISHNAN; AYYAPPANPILLAI AJAYAGHOSH
权利人:COUNCIL SCIENT IND RES
摘要:The present invention is concerned with a novel convergent route for synthesis of BCX-1777 and BCX-4430. Two key starting materials that were carefully chosen for cross-coupling were a stable sugar intermediate, unlike the imine intermediates in the prior art, and dihalogenated pyrrolopyrimidine intermediate. A chemoselective cross-coupling was achieved from the two key starting materials, which upon reduction and activation resulted in stereoselective formation of an advanced intermediate in 55% yield from protected D-ribonolactone in 6 steps. The advanced intermediate then served as a starting material for synthesis of BCX-1777 and BCX-4430 in 38% (over 8 steps) and 32% (over 9 steps) yields, respectively from protected D-ribonolactone.

专利号:US-10011580-B2
优先权日:2016-04-21
标题:Diastereoselective synthesis of (±)-epianastrephin, (±)-anastrephin and analogs thereof
发明人：WALSE SPENCER S; KUZMICH DANIEL
权利人:US AGRICULTURE
摘要:A process for the synthesis of trans-fused γ-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective synthesis of (±)-epianastrephin (1) (wherein: R 1 is ethenyl, R 2 and R 3 is methyl, and n is 1), (±)-anastrephin (2) (wherein: R 2 is ethenyl, R 1 and R 3 is methyl and n is 1), and analogs thereof (wherein: R 1 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 2 is H, C 1-5 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, R 1 and R 2 together with the carbon atom they are attached form a C 3-6 cycloalkyl ring, R 3 is C 1-5 alkyl and n is 0-2):

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:WO-2017063617-A1
优先权日:2015-10-13
标 题 :Preparation of intermediates for the synthesis of canagliflozin and dapagliflozin
发明人：ZEZULA JOSEF; BABIAK PETR; HAJDUCH JAN
权利人:ZENTIVA KS
摘要:The present invention relates to a preparation method of the intermediates of structures la (for the synthesis of canagliflozin) and 1b (for the synthesis of dapagliflozin), where in structure la X is methyl and Ar represents 2-(5-(4-fluorophenyl)-thienyl) and in structure 1b X is chlorine and Ar represents 4-ethoxyphenyl.