CAS: 934828-12-3; N-(2-Aminophenyl)-4-(1-((1,3-Dimethyl-1H-Pyrazol-4-yl)Methyl)Piperidin-4-yl)Benzamide
- 英文名称N-(2-Aminophenyl)-4-(1-((1,3-Dimethyl-1H-Pyrazol-4-yl)Methyl)Piperidin-4-yl)Benzamide
- 中文名称N-(2-氨基苯基)-4-[1-[(1,3-二甲基-1H-吡唑-4-基)甲基]-4-哌啶基]苯甲酰胺
- IUPAC名称N-(2-aminophenyl)-4-(1-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)benzamide
- 其它别名N-(2-Aminophenyl)-4-{1-[(1,3-Dimethyl-1H-Pyrazol-4-yl)Methyl]Piperidin-4-Yl}Benzamide; N-(2-Aminophenyl)-4-(1-((1,3-Dimethyl-1H-Pyrazol-4-yl)Methyl)Piperidin-4-yl)Benzamide; Zabadinostat [inn]; Chininu
- CAS编号934828-12-3
- MFCD编号:MFCD30489755
- FDA UNII编号:5TNV87ICD2
- 分子式:C24H29N5O分子量:403.53
- 产品CID: 1974460
- 同类组份化合物CAS934828-12-3 (free base)CXD101 HCl
- 产品分类Inhibitors/Agonists → Epigenetics → HDAC
物理性质
合成工艺路线路线简述
- 934828-13-4 = 934828-12-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; Rt -> 0 °C; 0 °C; 0 °C -> Rt; 18 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12
标题:Preparation Of 2-Aminobenzamides As Histone Deacetylase Inhibitors For The Treatment Of Tumors
参考文献:World Intellectual Property Organization]
= 934828-12-3 [标题:Reaction Conditions
标题:Benzamide Compounds Useful As Histone Deacetylase Inhibitors
参考文献:United States
海关参考信息
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2902700000-异丙基苯
2912110000-甲醛
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主要参考文献
1: Liu J, Qian C, Zhu Y, Cai J, He Y, Li J, Wang T, Zhu H, Li Z, Li W, Hu L. Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold. Bioorg Med Chem. 2017 Dec 29. pii: S0968-0896(17)32183-1. doi: 10.1016/j.bmc.2017.12.041. [Epub ahead of print] doi: 10.18632/oncotarget.22775. eCollection 2017 Dec 15.
5: Arrizabalaga O, Moreno-Cugnon L, Auzmendi-Iriarte J, Aldaz P, de Cáceres II, Garros-Regulez L, Moncho-Amor V, Torres-Bayona S, Pernía O, Pintado-Berninches L, Carrasco-Ramirez P, Cortes-Sempere M, Rosas R, Sanchez-Gomez P, Ruiz I, Caren H, Pollard S, Garcia I, Sacido AA, Lovell-Badge R, Belda-Iniesta C, Sampron N, Perona R, Matheu A. High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response. Oncogenesis. 2017 Dec 14;6(12):401. doi: 10.1038/s41389-017-0003-9. Review. doi: 10.1016/j.neulet.2017.12.037. [Epub ahead of print] doi: 10.1161/STROKEAHA.117.016674. Epub 2017 Dec 15. doi: 10.1016/j.jphs.2017.11.004. Epub 2017 Nov 24. doi: 10.3892/or.2017.6127. Epub 2017 Dec 1. doi: 10.1016/j.ejmech.2017.08.041. Epub 2017 Aug 22. doi: 10.3389/fnmol.2017.00357. eCollection 2017.
15: Liu TP, Hong YH, Yang PM. In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells. Oncotarget. 2017 Sep 16;8(49):86168-86180. doi: 10.18632/oncotarget.21030. eCollection 2017 Oct 17.
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