CAS: 90719-30-5; (S,E)-4-Benzyl-3-(But-2-Enoyl)Oxazolidin-2-One

该化合物是一个化学化合物,主要吸引人们对其在医学化学领域的潜在应用感兴趣,特别是在癌症研究方面,被归类为小分子抑制剂,具体针对细胞过程涉及的某些酶.复合物具有许多小分子抑制剂的典型特征,包括通过干扰酶活动调节生物路径的能力.Locostatin的结构包括有助于其约束性与目标特性的功能组,这对治疗应用的效果至关重要.此外,研究还表明,它可能具有抗生素特性,因此可以作为进一步发展癌症治疗的候选物.与这一类别中的许多化合物一样,了解其药理学,毒性和行动机制对于评价其作为治疗剂的潜力至关重要.必须开展进一步研究,以充分阐明其生物影响,并优化其在临床环境中的使用.

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物理性质

MSDS等安全信息

上下游产品

CAS号625-35-4 巴豆酰氯 | CAS号90719-32-7 |S|-4-苄基-2-恶唑烷酮 | CAS号10487-71-5 丁烯酰氯 | CAS号623-68-7 巴豆酸酐 | CAS号145589-03-3 (R)-3-(3-甲基丁酰)-... | CAS号133729-84-7 (3S,4s)-4-苄基-3-...

合成工艺路线路线简述

  • 90719-32-7 + 623-68-7 = 90719-30-5
    反应条件:1.1 Reagents: Triethylamine,Lithium Chloride Solvents: Tetrahydrofuran; -15 °C; -15 °C -> Rt; 12 H,Rt
    标题:Stereocontrolled Total Synthesis Of (-)-Kainic Acid
    作者:Sakaguchi,Hiroshi; Tokuyama,Hidetoshi; Fukuyama,Tohru
    参考文献:Organic Letters 日期:2007 卷标:9(9) 页码:1635-1638]

    90719-32-7 + 625-35-4 = 90719-30-5
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C
    标题:Labelling Of Gw796406X With (M+4)-Methylcopper
    作者:Wadsworth,Alan H.; Lawrie,Kenneth W. M.
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:2007 卷标:50(5-6) 页码:500-501]

    90719-32-7 + 625-35-4 = 90719-30-5
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 15 Min,-78 °C1.2 -78 °C; 30 Min,-78 °C; 15 Min,0 °C1.3 Reagents: Ammonium Chloride Solvents: Water
    标题:Palladium-Catalyzed Diastereoselective Synthesis Of 3-Arylbutanoic Acid Derivatives
    作者:Zhi,Wubin; Li,Jingya; Zou,Dapeng; Wu,Yusheng; Wu,Yangjie
    参考文献:Journal Of Organic Chemistry 日期:2017 卷标:82(23) 页码:12286-12293]

    90719-32-7 + 10487-71-5 = 90719-30-5
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-78 °C1.2 Solvents: Tetrahydrofuran; 30 Min,-78 °C; -78 °C -> Rt
    标题:Highly Diastereoselective Conjugate Additions Of Monoorganocopper Reagents To Chiral Imides
    作者:Dambacher,Jesse; Anness,Robert; Pollock,Patrick; Bergdahl,Mikael
    参考文献:Tetrahedron 日期:2004 卷标:60(9) 页码:2097-2110]

    90719-32-7 = 90719-30-5
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 15 Min,-78 °C1.2 30 Min,-78 °C; -78 °C -> 0 °C; 15 Min,0 °C1.3 Reagents: Ammonium Chloride Solvents: Water; 0 °C
    标题:A Concise Diels-Alder Strategy For The Asymmetric Synthesis Of (+)-Albicanol,(+)-Albicanyl Acetate,(+)-Dihydrodrimenin,And (-)-Dihydroisodrimeninol
    作者:Henderson,Jeff R.; Parvez,Masood; Keay,Brian A.
    参考文献:Organic Letters 日期:2009 卷标:11(15) 页码:3178-3181]

    90719-32-7 + 625-35-4 = 90719-30-5
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; Rt; 30 Min,Rt1.2 Rt; 5 H,Rt1.3 Reagents: Water; Rt
    标题:Stereoselective Synthesis Of An Alarm Pheromone Of Grematogaster Ants Using (4S)-4-Benzyloxazolidinone As Chiral Auxiliary
    作者:Zhou,F. Y.; Lu,C. F.; Chen,Z. X.; Yang,G. C.
    参考文献:Chemistry Of Natural Compounds 日期:2010 卷标:46(1) 页码:83-85
📜2-丁烯酰氯,(S)-4-苄基-2-唑烷酮置于正丁基锂体系中,用 四氢呋喃 作为反应溶剂,化学反应 12.33H,以66%的收率获得产物(4S)-N-巴豆酰基-4-异丙基-2-恶唑烷酮
参考文献:对映纯n-烯酰基恶唑烷-2-酮对映体纯双酰胺非对映选择性共轭加成:一种机理探针.
标题:对映纯n-烯酰基恶唑烷-2-酮对映体纯双酰胺非对映选择性共轭加成:一种机理探针.
摘要:N-苄基-N-(α-甲基苄基)酰胺锂的对映体向非对映纯n-烯酰基恶唑烷-2-酮的双非对映选择性共轭加成已被用作机械探针来确定反应构象是抗-š-顺式形式.由这些共轭加成反应得到的β-氨基羰基产物是有用的模板,用于进一步加工成α,β,α-伪三肽.
DOI:10.1016/j.Tetasy.2010.03.033

海关参考信息

专利信息


专利号:US-2003096374-A1
优先权日:1999-01-27
标题:Synthesis of oligoketides

专利号:WO-0044717-A2
优先权日:1999-01-27
标 题 :Synthesis of oligoketides

专利号:WO-0044717-A3
优先权日:1999-01-27
标题 :Synthesis of oligoketides

专利号:US-7022825-B2
优先权日:1999-01-27
标 题 :Polyketides and antibiotics
发明人：ASHLEY GARY; CHAN-KAI ISAAC C; BURLINGAME MARK A
权利人:KOSAN BIOSCIENCES INC
摘要:Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

专利号:EP-1754700-A2
优先权日:1999-01-27
标题 :Synthesis of oligoketides

专利号:AU-3353500-A
优先权日:1999-01-27
标 题:Synthesis of oligoketides

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主要参考文献

参考标题:Total Synthesis Of Both (+)-Compactin And (+)-Mevinolin. A General Strategy Based On The Use Of A Special Titanium Reagent For Dicarbonyl Coupling
作者:Derrick L. J. Clive,K. S. Keshava Murthy,Andrew G. H. Wee,J. Siva Prasad,Gil V. J. Da Silva,Marek Majewski,Paul C. Anderson,Claire F. Evans,Richard D. Haugen |发布日期:1990.4
摘要:A Strategy Is Described For Stereocontrolled Synthesis Of Hypocholesterolemic Compounds, (+)-Compactin(+)-Mevinolin

合成参考文献


摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 682.
摘要:Haufe, G., Science of Synthesis Knowledge Updates, (2019) 3, 250.
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