CAS: 885477-83-8; ((4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methylmethylsulfonamido)Pyrimidin-5-yl)Methyl)Triphenylphosphonium Bromide

相似化合物

799842-07-2 147118-37-4 147118-36-3

4-Methyl-3-Oxopentanoic Acid Benzyl Ester置于sodium Tetrahydroborate,三甲基氯硅烷,乙酸丁酯,硫酸,5%-Palladium/activated Carbon,氢气,硝酸,Potassium Carbonate,对甲苯磺酰氯,Copper(L) Chloride,Sodium Nitrite体系中,用 四氢呋喃,甲醇,二氯甲烷,甲苯 作为反应溶剂,化学反应 66.0H,反应生成 [4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰胺基)-5-嘧啶基]三苯基溴化膦
参考文献:瑞舒伐他汀钙的立体控制合成经由氯化碘诱导的分子内环化†
标题:瑞舒伐他汀钙的立体控制合成经由氯化碘诱导的分子内环化†
摘要:已经开发出一种从已知的(S)-均烯丙基醇制得的瑞舒伐他汀钙的新型立体选择性方法.该合成通过手性均烯丙基碳酸酯的区域和立体控制的ici诱导的分子内环化来突出,以递送具有顺-1,3-二醇部分的c 6-甲酰基他汀类侧链.罗苏伐他汀嘧啶核心部分的改进的合成也包括在内.此外,该方法学可用于他汀类药物的结构变体的不对称合成,例如匹伐他汀钙和阿托伐他汀钙及其相关类似物.
DOI:10.1039/c5Ob02245B

专利信息

专利号:US-8269001-B2
优先权日:2005-10-05
标题 :Process for the synthesis of HMG-CoA reductase inhibitors
发明人：CASAR ZDENKO
权利人:CASAR ZDENKO; LEK PHARMACEUTICALS
摘要:A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.

专利号:US-9376397-B2
优先权日:2009-02-02
标 题 :Key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; KOSMRLJ JANEZ
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates in general to the field of organic chemistry and in particular to the preparation of N-(4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide (I), N-(4-(4-fluorophenyl)-5-(bromomethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (II) and N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (III), key intermediates in preparation of Rosuvastatin.

专利号:US-2008300406-A1
优先权日:2005-10-05
标 题 :Process for the Synthesis of Hmg-Coa Reductase Inhibitors

专利号:AU-2006299018-B2
优先权日:2005-10-05
标题:Process for the synthesis of HMG-CoA reductase inhibitors

专利号:AU-2006299018-A1
优先权日:2005-10-05
标 题:Process for the synthesis of HMG-CoA reductase inhibitors

专利号:JP-2012516839-A
优先权日:2009-02-02
标 题 :Major intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof