CAS: 827026-45-9; 3-(4-Nitro-1-Oxoisoindolin-2-yl)Piperidine-2,6-Dione

上下游产品

4-氨基甲酰基-4-(4-硝基-1-氧代-1,3-二氢异吲哚-2-基)丁酸 4-Carbamoyl-4-(4-Nitro-1-Oxo-1,3-Dihydroisoindol-2-yl)Butyric Acid 1198299-72-7
2-(4-Nitro-1-Oxo-1,3-Dihydroisoindol-2-yl)Glutaric Acid Dimethyl Ester 827026-43-7
3-硝基邻苯二甲酰亚胺 4-Nitro-1H-Isoindole-1,3(2H)-Dione 603-62-3

Dl-谷氨酰胺置于盐酸,Ammonium Hydroxide,N-羟基丁二酰亚胺,氯化亚砜,碳酸氢钠,N,N'-二异丙基碳二亚胺体系中,用 四氢呋喃,甲醇,甲基叔丁基醚,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 73.33H,反应生成 3-(4-硝基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮
参考文献:一种来那度胺的制备方法
标题:一种来那度胺的制备方法
摘要:本发明提供了一种来那度胺的制备方法.所述来那度胺的制备方法包括制备中间体2‑卤甲基‑3硝基苯甲酸甲酯和中间体3‑氨基哌啶‑2,6‑二酮的步骤,以及利用这两个中间体制备来那度胺的步骤.所述来那度胺的制备方法步骤简单,收率较高,成本较低,有利于工业化生产.

专利信息

专利号:US-10392364-B2
优先权日:2014-08-11
标题:Process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; NANDIPATI RAMADEVI; GOODA RAVI; SHEWALKAR MUKESH PADMAKAR; BHADKE VENKAT VASANTRAO
权利人:AVRA LABORATORIES PVT LTD
摘要:Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

专利号:WO-2022144924-A1
优先权日:2021-01-04
标 题:An improved process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; SHEWALKAR MUKESH PADMAKAR
权利人:AVRA LABORATORIES PVT LTD
摘要:The present invention discloses an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof. More particularly, the invention relates to preparation of Lenalidomide with high yields and purity and to preparation of crystalline polymorphic form A and Form B.

专利号:US-2018334443-A1
优先权日:2014-08-11
标题:An improved process for synthesis of lenalidomide

专利号:US-9522899-B2
优先权日:2009-06-01
标 题:Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof
发明人：YAN RONG; YANG HAO; XU YONGXIANG
权利人:NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD; YAN RONG; NANJIAN CAVENDISH BIO-ENGINEERING TECH CO LTD
摘要:The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production.

专利号:WO-2016024286-A2
优先权日:2014-08-11
标 题 :An improved process for synthesis of lenalidomide

专利号:CN-111548341-B
优先权日:2020-06-16
标题:Chemical synthesis method of lenalidomide key intermediate