CAS: 76-54-0; 2',7'-Dichloro-3',6'-Dihydroxy-3H-Spiro[isobenzofuran-1,9'-Xanthen]-3-One

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CAS号518-45-6 荧光素 | CAS号4091-99-0 2-(3,6-二乙酰氧基-2,... | CAS号85-44-9 苯酐 | CAS号95-88-5 4-氯间苯二酚 | CAS号108-46-3 间苯二酚 | CAS号106070-31-9 2',7'-二氯二氢荧光素 | CAS号2044-85-1 2′,7′-二氯荧光素二乙酸酯 | CAS号88-99-3 邻苯二甲酸 | CAS号106070-31-9 2',7'-二氯二氢荧光素 | CAS号92-83-1 氧杂蒽 | CAS号2044-85-1 2′,7′-二氯荧光素二乙酸酯

Fluorescein Free Acid置于五氯化磷,N-甲基吡咯烷酮体系中,用 氯苯 作为反应溶剂,化学反应 6.0H,反应生成 二氯荧光黄
参考文献:Rhodamine Dye Derivatives And Their Use For Phase Change Inks
标题:Rhodamine Dye Derivatives And Their Use For Phase Change Inks

专利信息

专利号:US-2023235372-A1
优先权日:2020-06-12
标题:Ab-initio, template-independent synthesis of nucleic acids using thermostable enzymes
发明人：RANDRIANJATOVO-GBALOU IRINA; SAID AHMED; RAHIER RENAUD
权利人:SYNHELIX
摘要:The invention relates to the field of nucleic acid synthesis or sequencing, more specifically to methods for ab-initio synthesis of nucleic acids, comprising contacting a nucleotide with a free 3′-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3′-hydroxyl group of the nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of both ab-initio single-stranded nucleic acid synthesis activity and template-independent terminal nucleotidyl transferase activity.

专利号:US-2023235373-A1
优先权日:2020-06-12
标 题:Controlled template-independent synthesis of nucleic acids using thermostable enzymes
发明人：RANDRIANJATOVO-GBALOU IRINA; SAID AHMED; RAHIER RENAUD
权利人:SYNHELIX
摘要:The invention relates to methods for template-independent synthesis of nucleic acids, comprising iteratively contacting an initiator sequence comprising a 3′-end nucleotide with a free 3′-hydroxyl group, with at least one nucleoside triphosphate, or a combination of nucleoside triphosphates, in the presence of an archaeal DNA primase or a functionally active fragment and/or variant thereof, thereby covalently binding said nucleoside triphosphate to the free 3-hydroxyl group of the 3-end nucleotide. It also relates to isolated functionally active fragments of archaeal DNA primases which are capable of template-independent terminal nucleotidyl transferase activity but are devoid of a template-independent primase activity.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-8927584-B2
优先权日:2011-02-22
标 题:Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof
发明人：WANG JEH-JENG; LIAO CHAO-CHENG; Hu wan-ping; SHEN HO-CHUAN
权利人:UNIV KAOHSIUNG MEDICAL
摘要:The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R 1 and R 2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.

专利号:US-2025129187-A1
优先权日:2021-09-16
标题 :Methods for synthesis of dye-labeled polymers
发明人：SUGAR ANTONIA; SERAG MAGED FOUAD; HABUCHI SATOSHI; HOTEIT HUSSEIN ALI; ABADI MARAM MANSOOR
权利人:UNIV KING ABDULLAH SCI & TECH
摘要:Dye-labeled polymers formed from a polymer and a dye are disclosed. Methods for labeling a polymer with a dye are also disclosed. The polymer can have any weight average molecular weight (Mw), particularly a Mw of >5 megadalton (MDa) or >6 MDa. The polymer contains reactive group(s) that can be activated by an activation agent in a buffer solution. Upon activation, the polymer bundles and forms activated polymer in a solid form. The activated polymer can react with a reactive group of the dye to form the dye-labeled polymer. By soaking the dye-labeled polymer in a solid form in an aqueous solvent, the dye-labeled polymer can regain the viscosifying property that is the same or substantially the same as the polymer prior to labeling with the dye.