CAS: 74472-53-0; 2,3,3',4,4',5,5',6-Octachlorobiphenyl

该化合物是一种合成有机化合物,其复杂结构由两只双联苯环组成,8个氯原子在不同位置被替换,该化合物是更大的多氯联苯群体的一部分,众所周知,其化学稳定性,疏水性和耐降解性使这些多氯联苯成为持久性有机污染物. 2,3,3',4,4',4',5,5',5',6-八氯联苯一般没有颜色,光黄色和表现出低挥发性.它溶解于水中,但有机溶剂中溶解,这助长了其在食物链中的生物累积.由于其毒性特征,包括潜在的致癌效应和内分泌干扰,许多国家禁止使用或严格限制使用这种物质.目前正在进行环境监测和补救努力,以解决土壤和水生系统中与多氯联苯有关的污染,包括这种特定化合物.

英文名称2,3,3',4,4',5,5',6-Octachlorobiphenyl
中文名称2,3,3’,4,4’,5,5’,6-八氯联苯
IUPAC名称1,2,3,4,5-pentachloro-6-(3,4,5-trichlorophenyl)benzene
其它别名2,3,3',4,4',5,5',6-°Ctachlorobiphenyl; 2,3,4,5,6,3',4',5'-°Ctachlorobiphenyl
CAS编号74472-53-0
MFCD编号:MFCD00152688
FDA UNII编号:K1Y2JD283U
分子式:C12H2Cl8分子量:429.77
产品CID: 1734804
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: VXXBCDUYUQKWCK-UHFFFAOYSA-N
1S/C12H2Cl8/c13-4-1-3(2-5(14)7(4)15)6-8(16)10(18)12(20)11(19)9(6)17/h1-2H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4,5,6-pentachloroiodobenzene 1,2,3-trichloro-5-iodobenzene pentachlorobenzene 3,4,5-trichloroaniline

合成工艺路线路线简述

📜五氯苯,3,4,5-三氯苯胺置于亚硝酸异戊酯体系中,化学反应生成 2,3,3',4,4',5,5',6-八氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4