CAS: 7073-69-0; 2-(2-Bromophenyl)Propan-2-Ol

该化合物是一种溴化芳香醇,其第三类为氢氧基,成为有机合成的多用途中间体,其分子结构以苯环上的溴替代体为特征,通过诸如铃木或Heck反应等交叉反应,允许进一步发挥作用.第三类酒精会增强稳定性,同时提供一个反应场,供衍生.该化合物在制药和农用化学研究中特别有用,作为生物活性分子的前体.其定义明确的回活动性和与各种反应条件的兼容性使它成为建造复杂的芳香框架的宝贵建筑块.建议在惰性条件下储存以保持纯度.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号75-16-1 甲基溴化镁 | CAS号6091-64-1 2-溴苯甲酸乙酯 | CAS号676-58-4 甲基氯化镁 | CAS号917-64-6 甲基碘化镁 | CAS号2142-69-0 邻溴苯乙酮 | CAS号74-88-4 碘甲烷 | CAS号5411-56-3 1-(2-溴苯基)乙醇 | CAS号6630-33-7 2-溴苯甲醛 | CAS号7154-66-7 2-溴苯甲酰氯 | CAS号141754-15-6 1-bromo-2-(3-br... | CAS号221352-10-9 3,3-二甲基苯并[C][1,... | CAS号29574-51-4 6,6-dimethyl-6H... | CAS号120-14-9 藜芦醛; 3,4-二甲氧基苯甲醛 | CAS号217-59-4 三亚苯 | CAS号75295-57-7 2''-溴-[1,1'2',1... | CAS号934-53-2 ALFA, ALFA-二甲基苄氯 | CAS号577953-88-9 孟鲁司特二环己胺 | CAS号151767-02-1 孟鲁司特钠 | CAS号173026-23-8 1-(2-溴苯基)-1-甲基乙胺

合成工艺路线路线简述

  • 合成目标产物 2-(2-Bromophenyl)-2-Propanol 主要起始原料 Methyl 2-Bromobenzoate And Methylmagnesium Bromide
  • (文献来源)合成步骤主要原料 Methyl 2-Bromobenzoate 和 Methylmagnesium Bromide
📜邻溴苯甲酸甲酯置于甲基碘化镁体系中,化学反应生成 2-(2-溴苯基)-2-丙醇
参考文献:Substituted 1,3-Dihydrospiro(Isobenzofuran)S
标题:Substituted 1,3-Dihydrospiro(Isobenzofuran)S
摘要:描述了一种替代的1,3-二氢螺[异苯并呋喃]类化合物及其制备方法.这些化合物可用作抗抑郁药,镇定剂,镇痛剂和它们的中间体.

海关参考信息

专利信息


专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:CN-116969999-A
优先权日:2022-04-22
标题 :Synthesis and application of a new bidentate nitrogen ligand palladium complex

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 130.
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 131.
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