CAS: 60200-06-8; 4-Amino-6-(1,2,2-Trichlorovinyl)Benzene-1,3-Disulfonamide

结构式图片

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上下游产品

CAS号704-22-3 3-(1,2,2-三氯乙烯)苯胺 | CAS号700-60-7 Benzene,(1,2,2-... | CAS号4714-36-7 1-nitro-4-(1,2,... | CAS号721-24-4 3-Nitro Penta C... | CAS号63630-17-1 4-(Trichlorethe... | CAS号710-72-5 3-pentachloroet... | CAS号63630-19-3 2-nitro-4-(1,2,... | CAS号63630-18-2 2-nitro-4-(1,2,... | CAS号60285-85-0 4-amino-6-(1,2,...

合成工艺路线路线简述

  • 合成目标产物 Clorsulon 主要起始原料 4-Amino-6-(Trichlorovinyl)Benzene-1,3-Disulphonyl Dichloride
  • (文献来源)合成步骤主要原料 4-Amino-6-(Trichlorovinyl)Benzene-1,3-Disulphonyl Dichloride
4-氨基-6-(三氯乙烯基)苯-1,3-二磺酰二氯置于ammonium Hydroxide体系中,用 二氯甲烷 作为反应溶剂,以54.2%的收率获得产物克洛索隆
参考文献:一种氯舒隆的合成方法
标题:一种氯舒隆的合成方法
摘要:本发明提供一种氯舒隆的合成方法,所述方法以间硝基苯甲醛和三氯甲烷为初始原料,依次经缩合反应,氯代反应,消去反应,还原反应,氯磺化反应,胺化反应制得氯舒隆;其中,所述还原反应在含有盐酸,铁粉和硅藻土的体系中进行.本发明方法所获得的产品质量稳定,收率高,并且工艺相对简单,可操作性强,安全系数高,具备非常好的工业化前景.

海关参考信息

专利信息


专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:WO-2021009026-A1
优先权日:2019-07-12
标 题 :Methyl 2-[(4-methoxyimino-tetralin-6-yl]prop-2-enoate derivatives, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1h-isobenzofurane and indane analogues thereof, and similar compounds, as agrochemical fungicides
发明人:WEISS MATTHIAS; WILLIAMS SIMON; RENDINE STEFANO; BOU HAMDAN FARHAN; HOFFMAN THOMAS; QUARANTA LAURA
权利人:SYNGENTA CROP PROTECTION AG
摘要:Compounds of formula (I): (Formula (I)) Formula (I) encompasses e.g. tetraline, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1H-isobenzofurane and indane derivatives. The compounds of formula (I) are useful as a pesticides, especially as fungicides. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 53 to 78; examples 1 to 10; table T1; compounds 1.1 to 1.54; examples A and B). Preferred compounds are e.g.: Methyl (E)-3-methoxy-2-[(4E)-4-methoxyimino-7-methyl-tetralin-6- yl]prop-2-enoate (example 2; compound 1.6 of table T1): (Formula (A)). Methyl (E)-3-methoxy-2-[(4Z)-4-methoxyiminoisochroman-6-yl]prop-2- enoate (example 6; compound 1.39 of table T1): (Formula (B))

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:WO-2015132592-A1
优先权日:2014-03-06
标 题 :Novel isoxazolines and their use in controlling pests
发明人:MCCOOEY SEAMUS; MANIKOWSKI ANDRZEJ
权利人:NORBROOK LAB LTD
摘要:Disclosed herein are novel isoxazoline compounds of the general formula (I), compositions comprising these novel compounds, and uses of these compounds in the control of pests in both animal health and plant protection contexts. The compounds can be combined with other biologically active materials such as organophosphate pesticides, carbamate -type pesticides, organochlorine type pesticides, pyrethrins/pyrethroids, neonicotinoids, avermectins, milbemycins, benzimidazoles, salicylanilides, substituted phenols, pyrimidines, tetrahydropyrimidines, imidazothiazoles, amino/amido acetonitrile derivatives, febantel, clorsulon, levamisole, morantel, and praziquantel, juvenile hormone mimics and chitin synthesis inhibitors. (I)
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主要参考文献


1: Dermauw V, Meas S, Chea B, Onkelinx T, Sorn S, Holl D, Charlier J, Vercruysse J, Dorny P. Effects of anthelmintic treatment and feed supplementation on parasite infections and morbidity parameters in Cambodian cattle. Vet Parasitol. 2017 Feb 15;235:113-122. doi: 10.1016/j.vetpar.2017.01.018. Epub 2017 Jan 22. doi: 10.1016/j.pep.2017.02.005. Epub 2017 Feb 10. Epub 2016 Nov 12.
4: Saad AS, Ismail NS, Soliman M, Zaazaa HE. Validated Stability-Indicating RP-HPLC Method for Simultaneous Determination of Clorsulon and Ivermectin Employing Plackett-Burman Experimental Design for Robustness Testing. J AOAC Int. 2016 Mar-Apr;99(2):571-8. doi: 10.5740/jaoacint.15-0128. Epub 2016 Mar 18. Review. doi: 10.1016/j.vetpar.2015.02.014. Epub 2015 Feb 23. doi: 10.1136/vr.102720. Epub 2014 Dec 30. doi: 10.1007/s00436-014-3934-5. Epub 2014 May 16. doi: 10.1016/j.exppara.2013.10.010. Epub 2013 Nov 6. doi: 10.1016/j.vetpar.2013.05.006. Epub 2013 May 14. doi: 10.1002/dta.1467. Epub 2013 Apr 10. doi: 10.1007/s00436-013-3321-7. Epub 2013 Feb 28. German. doi: 10.1016/j.vetpar.2012.04.019. Epub 2012 Apr 20. Review. doi: 10.1080/19440049.2010.542775. Epub 2011 Jan 14. doi: 10.1016/j.vetpar.2010.09.034. Epub 2010 Oct 8. doi: 10.1016/j.cbi.2010.05.013. Epub 2010 Jun 1. doi: 10.1016/j.vetpar.2009.03.032. Epub 2009 Mar 27.

合成参考文献


摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
参考文献:10.1007/s00436-003-1036-x
摘要:Meaney M, Fairweather I, Brennan GP, Forbes AB. Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res. 2004 Feb;92(3):232–41. doi: 10.1007/s00436-003-1036-x.
参考文献:10.1016/s0304-4017(02)00130-9
摘要:Loyacano AF, Williams JC, Gurie J, DeRosa AA. Effect of gastrointestinal nematode and liver fluke infections on weight gain and reproductive performance of beef heifers. Vet Parasitol. 2002 Aug 02;107(3):227–34. doi: 10.1016/s0304-4017(02)00130-9.
参考文献:10.1186/1746-6148-6-8
摘要:Ceballos L, Moreno L, Alvarez L, Shaw L, Fairweather I, Lanusse C. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes. BMC Veterinary Research. 2010 Feb 03;6(1):8. doi: 10.1186/1746-6148-6-8.
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