📜环己烷丙二酸置于盐酸体系中,化学反应生成 环己基乙酸乙酯 参考文献:Freundler,Bulletin De La Societe Chimique De France,1906,Vol. <3> 35,P. 545 标题:Freundler,Bulletin De La Societe Chimique De France,1906,Vol. <3> 35,P. 545
专利号:US-4338466-A 优先权日:1981-04-02 标 题 :Prostaglandin analogs and process of preparation thereof 发明人:NELSON GEORGE L 权利人:US NAVY 摘要:Prostaglandin analogs and process for the preparation thereof as precursors for the synthesis of oligomeric mixtures exhibiting biological activity for protection of oxidative phosphorylation of degraded mitochondria. The analogs have the general formula: synthesized by O-alkylating a 2-alkylcyclopentane-1,3-dione to form an enol ether, reacting the ether with CH2=CHMgBr to form a vinyl, oxidizing the vinyl with OsO4 and NaIO4 to form an aldehyde, and reacting the aldehyde with a sodium salt of dimethyl (2-oxoalkyl)phosphonate.
专利号:EP-2097079-B1 优先权日:2006-11-30 标题:Modulation of prostaglandin/cyclooxygenase metabolic pathways 发明人:WUELFERT ERNST 权利人:HUNTER FLEMING LTD 摘要:A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy-steroids or condensed indoles.
专利号:US-10974236-B2 优先权日:2016-11-10 标 题 :Use of ruthenium complexes in olefin metathesis reaction 发明人:SKOWERSKI KRZYSZTOF; GAWIN RAFAL; CHWALBA MICHAL PAWEL 权利人:APEIRON SYNTHESIS SA 摘要:The invention relates to the use of ruthenium complexes, which are homogeneous catalysts and/or precatalysts of the olefin metathesis reaction, which lead to the production of alkenes containing an internal (non-terminal) double Câ•?C bond.
专利号:US-2009264648-A1 优先权日:2008-01-14 标题:Synthesis of pyrazoles 发明人:CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO 权利人:WYETH CORP; SIENA BIOTECH SPA 摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
专利号:US-7935827-B2 优先权日:2003-12-31 标题 :Optically active, heteroaromatic β-hydroxy esters and processes for their preparation from β-keto esters and processes for the preparation of these β-keto esters 发明人:PLATZEK JOHANNES; ZORN LUDWIG; BUCHMANN BERND; SKUBALLA WERNER; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
专利号:US-5733755-A 优先权日:1995-11-24 标题 :Method for the enantioselective synthesis of chiral derivatives of S-3-(4'-t 发明人:SUNJIC VITOMIR; MAJERIC MAJA; HAMERSAK ZDENKO; AVDAGIC AMIR 权利人:CAFFARO SPA IND CHIM 摘要:A method for manufacturing S-3-(4'-tert-butyl)-phenyl-2-methyl propylamines having the structure I ##STR1## where NR 1 R 2 is a dialkylamine group, pyrrolidine, piperidine, or cis-3,5-dimethyl morpholine, comprising a reduction of the compound having the structure II ##STR2##
1: Chitta R, Macko T, Brüll R, Kalies G. Elution behavior of polyethylene and polypropylene standards on carbon sorbents. J Chromatogr A. 2010 Dec 3;1217(49):7717-22. doi: 10.1016/j.chroma.2010.10.036. Epub 2010 Oct 14.
合成参考文献
摘要:Caballero, A.; Díaz-Requejo, M. M.; Pérez, P. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 160. 摘要:Caballero, A.; Díaz-Requejo, M. M.; Pérez, P. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 163. 摘要:Kim, H.; Yoshida , J., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 225. 摘要:Caballero, A.; Díaz-Requejo, M. M.; Pérez, P. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 160. 摘要:Bao, Z.; Wang, J., Science of Synthesis: Knowledge Updates, (2023) 2, 22.