CAS: 526-55-6; 3-Indoleethanol

上下游产品

CAS号87-51-4 吲哚-3-乙酸 | CAS号160194-28-5 1-三乙基硅烷-4-三乙基硅氧... | CAS号615-36-1 2-溴苯胺 | CAS号1912-33-0 吲哚-3-乙酸甲酯 | CAS号778-82-5 3-吲哚乙酸乙酯 | CAS号1191-99-7 2,3-二氢呋喃 | CAS号59-88-1 盐酸苯肼 | CAS号18372-22-0 吲哚-3-乙醛酸甲酯 | CAS号201230-82-2 carbon monoxide | CAS号107-18-6 烯丙醇 | CAS号61-50-7 N,N-二甲基色胺 | CAS号1912-33-0 吲哚-3-乙酸甲酯 | CAS号3389-21-7 3-(2-溴乙基)吲哚 | CAS号86658-78-8 (2-INDOL-3-YLET... | CAS号87-51-4 吲哚-3-乙酸 | CAS号61-54-1 色胺 | CAS号61-49-4 N-ω-甲基色胺 | CAS号101079-48-5 tert-butyl-[2-(... | CAS号15741-71-6 2-(2-(1H-吲哚-3-基... | CAS号32933-86-1 3-(2-氯乙基)-1H-吲哚

吲哚-3-乙腈置于lithium Aluminium Tetrahydride,Potassium Hydroxide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 21.0H,反应生成 色醇
参考文献:Fecl3活化的c3亲电n-乙酰丁醇的区域选择性加氢芳基化反应:进入3-(杂)芳林多林的入口.
标题:Fecl3活化的c3亲电n-乙酰丁醇的区域选择性加氢芳基化反应:进入3-(杂)芳林多林的入口.
摘要:报道了直接和罕见地对吲哚的3位进行定位的方法.的活化ñ-Acetylindole与铁(iii),氯化允许ç 小时加入的芳族和杂芳族底物的在吲哚核的c2c3双键以产生c3和引线的季中心区域选择性为3-Arylindolines.本文介绍了该过程的优化,范围(50个示例),实用性(克规模,空气气氛,室温)以及机械原理.还描述了吲哚啉产物向药物样化合物的合成转化.
DOI:10.1002/chem.201400284

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-6660283-B2
优先权日:1997-12-19
标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-5567824-A
优先权日:1994-05-24
标 题 :Palladium catalyzed ring closure of triazolyltryptamine
发明人：CHEN CHENG Y; LARSEN ROBERT D; VERHOEVEN THOMAS R
权利人:MERCK & CO INC
摘要:A new process is described for the synthesis of the triazolyl tryptamine: and related compounds. The process involves a palladium-catalyzed ring closure between a substituted ortho-iodoaniline and a protected 1-alkynol. The process is carded out at high temperature, e.g. 100 DEG C., in a dry inert solvent, e.g., DMF and in the presence of a proton acceptor, e.g., Na2CO3 or a trialkylamine. The triazolyl tryptamine, as well as acid addition salts thereof, is a 5 HT1D receptor agonist having anti-migraine properties.