CAS: 51568-18-4; 4,6-Dioxoheptanoic Acid

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502-50-1 127528-53-4 80480-42-8

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CAS号79-11-8 氯乙酸 | CAS号123-54-6 乙酰丙酮

📜氯乙酸,乙酰丙酮 反应生成 4,6-二氧代庚酸
参考文献:Synthesis Of Dioxocarboxylic Acids
标题:Synthesis Of Dioxocarboxylic Acids
摘要:
DOI:10.1021/jo00929A035

专利信息

专利号:WO-9000049-A3
优先权日:1988-06-29
标 题 :Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consist of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have formula (I), wherein n = 1-6; R = CH3, CF3, -CO2RIV, (a), or (b); RI, RII = H, F, CH¿3?, or (c); R?III¿ = H, -CO¿2R?IV, (d), (e), or tetrazolyl; RIV = H, or alkyl; and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-5216005-A
优先权日:1989-03-15
标题:Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-5173482-A
优先权日:1989-03-15
标 题 :Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-4895872-A
优先权日:1989-03-15
标题:Immunosupressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPAPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-5252603-A
优先权日:1989-03-15
标题 :Immunosuppressive analogues and derivatives of succinylacetone
发明人：NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
权利人:CETUS CORP
摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n=1-6 R=CH3, CF3, -CO2RIV, RI, RII=H, F, CH3, or RIII=H, or tetrazolyl RIV=H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

专利号:US-2024285670-A1
优先权日:2021-06-11
标题 :Therapeutic treatment of tumors by blocking the heme synthesis-export axis
发明人：TOLOSANO EMANUELA; FIORITO VERONICA; PETRILLO SARA; CHIABRANDO DEBORAH; ALLOCCO ANNA LUCIA; BERTINO FRANCESCA
权利人:UNIV DEGLI STUDI DI TORINO
摘要:A blocker of heme synthesis-export axis as active agent for use in the treatment of a tumor in a subject, wherein the blocker of heme synthesis-export axis upmodulates oxidative metabolism of tumor cells by upregulating the tricarboxylic acid (TCA) cycle and the oxidative phosphorylation (OXPHOS).