CAS: 482-70-2; 2,7-Dimethylnaphthalene-1,4-Dione

该化合物是一种二甲基替代的氯化萘衍生物,可能用于有机合成和材料科学,其五类结构具有红氧化活性,在电子转移过程中有用,并作为功能材料的构件.2,7个基点的甲基组在维持标准条件下的稳定性的同时,提高了有机溶剂的溶解性.该化合物可作为染料,药品或电动聚合物合成的中间体.其明确界定的结构允许精确修改,便于研究和工业工艺中的特定应用.产品通常供应纯度高,确保实验和生产环境中的再生性.

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物理性质

MSDS等安全信息

上下游产品

CAS号582-16-1 2,7-二甲基萘 | CAS号52062-24-5 1-acetoxy-3-met... | CAS号19832-87-2 2-氯-5-甲基-1,4-苯醌 | CAS号412321-01-8 2,7-Dimethyl-5,... | CAS号553-97-9 甲基苯醌 | CAS号78-79-5 异戊二烯 | CAS号33121-78-7 3,7-dimethyl-na... | CAS号64-19-7 冰醋酸 | CAS号528-44-9 1,2,4-苯三甲酸

合成工艺路线路线简述

    📜甲基苯醌置于sodium Dichromate,硫酸,Sodium Nitrite体系中,用 溶剂黄146 作为反应溶剂,化学反应生成 2,7-二甲基-1,4-萘醌
    参考文献:Uber Die Bestandteile Der Pyrolazeen. Xi. Die Bestandteile Der Pyrola Renifolia Maxim. (1).
    标题:Uber Die Bestandteile Der Pyrolazeen. Xi. Die Bestandteile Der Pyrola Renifolia Maxim. (1).
    摘要:从羽叶乌头(pyrola Renifolia Maxim.)中提取出了chimaphilin,这是一种似乎是单糖苷的葡萄糖苷,同时还分离出了一个新的葡萄糖苷.后者被称为renifolin,证明是2,7-二甲基-5,8-二氢-1,4-萘醌的β-葡萄糖苷.
    DOI:10.1248/cpb.12.533

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    专利信息


    专利号:US-9409879-B2
    优先权日:2011-03-29
    标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
    发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
    权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
    摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

    专利号:US-2014121238-A1
    优先权日:2011-03-29
    标 题:Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

    专利号:WO-2012131010-A1
    优先权日:2011-03-29
    标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

    专利号:EP-2691372-A1
    优先权日:2011-03-29
    标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

    专利号:EP-2691372-B1
    优先权日:2011-03-29
    标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents

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    主要参考文献


    1: Ma WD, Zou YP, Wang P, Yao XH, Sun Y, Duan MH, Fu YJ, Yu B. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8. doi: 10.1016/j.fct.2014.04.014. Epub 2014 May 1.
    237:25-30. doi: 10.1016/j.cbi.2015.05.008. Epub 2015 May 15. 96(1):1-7. doi: 10.1139/cjpp-2016-0522. Epub 2017 Jan 29. 19(3):180-3. doi: 10.1111/j.1600-0536.1988.tb02890.x.
    169:270-6. doi: 10.1016/j.foodchem.2014.07.115. Epub 2014 Aug 5. 69(3):738-46. doi: 10.1016/j.phytochem.2007.09.007. Epub 2007 Oct 22. 55(9):445. doi: 10.1007/BF00602667. a biotechnological perspective on the coming-of-age prince's pine. Phytochem Rev. 2023 Jun

    合成参考文献


    参考文献:10.1139/cjpp-2016-0522
    摘要:Dong F, Liu T, Jin H, Wang W. Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways. Can J Physiol Pharmacol. 2018 Jan;96(1):1–7. doi: 10.1139/cjpp-2016-0522.
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