CAS: 4058-91-7; 5-Amino-1-Methyl-1H-Pyrazole-4-Carboxylic Acid

相似化合物

31037-02-2 5334-41-8 110860-60-1

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CAS号31037-02-2 5-氨基-1-甲基吡唑-4-甲酸乙酯 | CAS号5334-41-8 1-甲基-4-氰基-5-氨基-... | CAS号18213-77-9 1-甲基-5-硝基吡唑-4-甲酸

📜5-氨基-1-甲基-吡唑-4-甲腈置于水,Sodium Hydroxide体系中,化学反应生成 5-氨基-1-甲基吡唑-4-甲酸
参考文献:Pf-04859989作为基于结构的药物设计的模板:鉴定具有改善的亲脂性效率的新型吡唑系列不可逆kat Ii抑制剂
标题:Pf-04859989作为基于结构的药物设计的模板:鉴定具有改善的亲脂性效率的新型吡唑系列不可逆kat Ii抑制剂
摘要:本文描述了新的吡唑系列不可逆kat Ii抑制剂的基于结构的设计,合成和生物学评估.从二氢喹啉酮核心到四氢吡唑并吡啶并酮核心的1和2抑制剂骨架的修饰导致发现了一系列新的有效kat Ii抑制剂,这些抑制剂具有出色的理化性质.在这些新的吡唑类似物中,化合物20是最有效和亲脂性最强的化合物,其k Inact / K I值为112,000 M-1 S-1,亲脂性效率(lipe)为8.53.x射线晶体结构为20 Kat Ii的使用证明了有助于实现这种非凡效能和结合效率的关键功能.
DOI:10.1016/j.Bmcl.2013.02.039

专利信息

专利号:US-5663366-A
优先权日:1992-10-16
标 题:Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair
发明人：NEUNHOEFFER HANS; GERSTUNG STEFAN; CLAUSEN THOMAS; BALZER WOLFGANG R
权利人:WELLA AKTIENGESELLSCHAT
摘要:The subject matter of the present invention is directed to a process for producing 4,5-diaminopyrazole derivatives of the general formula (I) (I) where R1 and R2 independently designate hydrogen, a C1- to C6-alkyl radical or a C2- to C4-hydroxyalkyl radical, which can be used as dye precursors, for example for hair dyes, and to new pyrazole derivatives. When using the process according to the invention good yields of isomer-pure 4,5-diaminopyrazole derivatives of general formula (I) can be obtained.

专利号:US-5534267-A
优先权日:1992-10-16
标题 :Composition for the oxidative dyeing of hair containing 4,5-diaminopyrazole derivatives as well as new 4,5-diaminopyrazole derivatives and process for their synthesis
发明人：NEUNHOEFFER HANS; GERSTUNG STEFAN; CLAUSEN THOMAS; BALZER WOLFGANG R
权利人:WELLA AG
摘要:The composition for oxidative dyeing of hair based on a combination of developer substances and coupler substances, contains as a developer substance 4,5-diamino-1-(4'-methoxybenzyl)pyrazole, 4,5-diamino-1-(4'-methylbenzyl)pyrazole, 4,5-diamino-1-(4'-chlorobenzyl)pyrazole, 4,5-diamino-1-(3'-methoxybenzyl)pyrazole, 4-amino-1-(4'-methoxy-benzyl) -5-methylaminopyrazole or 4-amino-5-(2'-hydroxyethyl)amino-1-(4'-methoxybenzyl)pyrazole.