CAS: 34626-51-2; 5-Bromopentan-1-Ol

相似化合物

15848-22-3 1014-93-3 85514-43-8

上下游产品

CAS号142-68-7 四氢吡喃 | CAS号15848-22-3 5-溴戊基乙酸酯 | CAS号2067-33-6 5-溴戊酸 | CAS号111-29-5 1,5-戊二醇 | CAS号14660-52-7 5-溴戊酸乙酯 | CAS号5454-83-1 5-溴戊酸甲酯 | CAS号7664-93-9 硫酸 | CAS号110-87-2 3,4-二氢-2H-吡喃 | CAS号407-97-6 1-溴-5-氟戊烷 | CAS号87227-41-6 2-(4-溴丁基)-1,3-二氧戊环 | CAS号334-20-3 (E)-9-Oxo-2-dec... | CAS号63478-76-2 6-庚炔醇 | CAS号54512-75-3 1-溴-5-氯戊烷 | CAS号139883-16-2 5-bromopentyl p... | CAS号112-47-0 1,10-癸二醇 | CAS号34626-52-3 5-hydroxypentyl... | CAS号36219-80-4 7-oxo°Ctanal | CAS号3523-02-2 HEXANENITRILE, 6-OXO

四氢吡喃置于三溴化硼体系中,用 二氯甲烷,甲醇 作为反应溶剂,化学反应 2.5H,以85%的收率获得产物5-溴-1-戊醇
参考文献:研究了孟买他汀的全合成,孟买他汀是一种高效的6-磷酸葡萄糖转运酶抑制剂.孟买他汀类似物的合成.
标题:研究了孟买他汀的全合成,孟买他汀是一种高效的6-磷酸葡萄糖转运酶抑制剂.孟买他汀类似物的合成.
摘要:拟定了高效合成6-磷酸葡萄糖转运酶抑制剂孟买他汀(1)和结构类似物的全合成策略.这些化合物代表了潜在的治疗糖尿病的新药开发的先导结构.为了评估总体策略,以收敛的方式合成了紧密的孟买他汀类似物10.蒽醌结构单元20通过芳烃/邻苯二甲酰亚胺环化而有效地制备.在将20转化为相应的9,10-二甲氧基蒽-1-甲醛衍生物(13)之后,与锂化的芳烃(12)偶联,然后在琼斯条件下进行多次氧化,得到孟买他汀类似物10.官能化芳烃中间体的制备为通过高度区域选择性的溴化和邻位锂化反应实现的.
DOI:10.1021/jo026232T

专利信息

专利号:US-2025162968-A1
优先权日:2022-02-02
标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids
发明人：ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A
权利人:NANOVATION THERAPEUTICS INC
摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-7211590-B2
优先权日:2002-08-01
标 题:Nitrosated proton pump inhibitors, compositions and methods of use
发明人：FANG XINQIN; GARVEY DAVID S; LETTS L GORDON
权利人:NITROMED INC
摘要:The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-3825607-A
优先权日:1972-01-17
标题 :Synthesis of 1-bromo-trans-3,trans-5-heptadiene
发明人：DESCOINS C; HENRICK C
权利人:ZOECON CORP
摘要:1-HALO-3,5-HEPTADIENE, PREPARED BY THE ACTION OF AQUEOUS HYDROPHALIC ACID ON 1-CYCLOPRROPYL-2-BUTEN-1-OL WHICH MAY BE PREPARED BY A GRIGNARD REACTION BETWEEN CROTONALDEHYDE AND CYCLOPROPYL MAGNESIUM HALLIDE OR BETWEEN CYCLOPROPYL CYANIDE AND 1-PROPYNYL MAGNESIUM HALIDE. IT IS USEFUL IN PREPARING 8.10-DODECADIENOL, A KNOWN CODLING MOTH SEX ATTRACTANT.

专利号:WO-2023147657-A1
优先权日:2022-02-02
标题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids