CAS: 34367-04-9; Ginsenoside Ro

📜(2S,3S,4S,5R,6R)-6-[[(3S,4Ar,6Ar,6Bs,8As,12As,14Ar,14Br)-4,4,6A,6B,11,11,14B-Heptamethyl-8A-[(2S,3R,4S,5R,6R)-3,4,5-Tribenzoyloxy-6-(Benzoyloxymethyl)Oxan-2-Yl]Oxycarbonyl-1,2,3,4A,5,6,7,8,9,10,12,12A,14,14A-Tetradecahydropicen-3-Yl]Oxy]-4-Benzoyloxy-3-Hydroxy-5-[(2S,3R,4S,5R,6R)-3,4,5-Tribenzoyloxy-6-(Benzoyloxymethyl)Oxan-2-Yl]Oxyoxane-2-Carboxylic Acid置于sodium Methylate体系中,用 甲醇,二氯甲烷 作为反应溶剂,以72%的收率获得产物人参皂苷ro
参考文献:Facile Synthesis Of Ginsenoside Ro
标题:Facile Synthesis Of Ginsenoside Ro
摘要:我们开发了两条简明的合成路线,它们在糖基化顺序上有所不同,最终都导向人参皂苷 Ro (1).这些合成路线的特点是,在后期通过 Tempo 介导的选择性氧化来处理葡萄糖醛酸残基,并引入 Azmb 作为邻苯甲酰基参与基团,以便日后选择性去除.
DOI:10.1055/s-2003-44985

专利信息

专利号:US-5747538-A
优先权日:1994-03-18
标 题 :Use of ginsenoside R0 or a plant extract containing same to promote collagen synthesis
发明人：MEYBECK ALAIN; BONTE FREDERIC; DUMAS MARC; CHAUDAGNE CATHERINE
权利人:LVMH RECH
摘要:PCT No. PCT/FR95/00326 Sec. 371 Date Sep. 18, 1996 Sec. 102(e) Date Sep. 18, 1996 PCT Filed Mar. 17, 1995 PCT Pub. No. WO95/25524 PCT Pub. Date Sep. 28, 1995The use of ginsenoside R0 or a plant extract containing same to prepare a cosmetic or pharmaceutical composition, particularly a skin care composition, for promoting collagen synthesis, particularly collagen I and/or collagen III synthesis. Said cosmetic or pharmaceutical composition is administered to a mammal, particularly a human being, in order to promote collagen synthesis. A method for promoting collagen synthesis in fibroblast growth media is also disclosed.

专利号:FR-2717389-B1
优先权日:1994-03-18
标题:Use of ginsenoside Ro or a plant extract containing it to stimulate the synthesis of collagen.

专利号:US-6641848-B1
优先权日:1998-05-29
标题:Saponin or sapogenol compositions for increasing collagen IV synthesis
发明人：BONTE FREDERIC; DUMAS MARC; PERRIER PIERRE
权利人:DIOR CHRISTIAN PARFUMS
摘要:The present invention relates in general terms to the use of saponins or sapogenols, particularly those extracted from a plant, preferably from soya or Medicago, in cosmetology and for the manufacture of pharmaceutical compositions for treating the skin in order to increase the amount of collagen IV in the dermo-epidermal junction. It further relates to novel cosmetic or pharmaceutical compositions which promote an increase in the amount of collagen IV in the dermo-epidermal junction, and to a method of cosmetic treatment using a saponin or a sapogenol. The invention is applicable in cosmetics, preferably in an anti-wrinkle treatment, and in pharmacy in the treatment of diseases associated with a deficiency of the dermo-epidermal junction resulting from an insufficient amount of collagen IV.

专利号:ES-2216303-T3
优先权日:1997-08-11
标 题:USE OF POLYGONATUM EXTRACTS TO STIMULATE THE SYNTHESIS OF THE CUTANEOUS ELASTINE.

专利号:ES-2209197-T3
优先权日:1997-08-08
标 题 :USE OF GINSENOSIDE RB1 TO STIMULATE THE SYNTHESIS OF ELASTINE.

专利号:NL-1003883-C2
优先权日:1995-08-25
标题:The use of Vitamin C or its derivative or analogous compounds to stimulate the synthesis of elastin in the skin.