CAS: 31570-39-5; (–)-(R)-Cembrene A

上下游产品

甜橙提取物 D-Limonene 5989-27-5
(3R,6E,10E)-6,10-Dimethyl-3-Isopropenylpentadeca-6,10-Dien-1-Al 79859-58-8
(2E,6E,10E)-(1R,14S)-14-Isopropenyl-3,7,11-Trimethyl-Cyclotetradeca-2,6,10-Trienol 59686-17-8

📜甜橙提取物置于正丁基锂,二甲基硫,4 A Molecular Sieve,Silica Gel,四氯化钛,对甲苯磺酸,臭氧,锌体系中,用 乙二醇二甲醚,丙酮 用作溶剂,化学反应 11.0H,反应生成(1E,5E,9E,12R)-1,5,9-三甲基-12-丙-1-烯-2-基环十四烷并-1,5,9-三烯
参考文献:Studies On Macrocyclic Diterpenoids (Xvii): Total Synthesis Of (-)-Cembrene-A And (+)-3,4-Epoxycembrene-A By Titanium-Induced Carbonyl Coupling Reactions
标题:Studies On Macrocyclic Diterpenoids (Xvii): Total Synthesis Of (-)-Cembrene-A And (+)-3,4-Epoxycembrene-A By Titanium-Induced Carbonyl Coupling Reactions
摘要:以 (E)-香叶基丙酮 (6) 和 (R)-柠檬烯为起始原料,高效全合成 (R)-西松烯-A (1) 和 (+)-3,4-环氧西松烯-A (2) 这两种海洋西松烯类化合物(7) 进行了描述.关键步骤是通过改进的维蒂希烯化反应从膦酸酯 4 和光学活性酮 5 合成烯烃 12,以及钛诱导的羰基醛 3 分子内偶联得到西柏烯-A (1). 3 的频哪醇偶联产生二醇 13,将其转化为 3,4-环氧西柏烯-A (2).
Doi:10.1055/s-1996-4290

专利信息

专利号:US-2019106684-A1
优先权日:2016-03-16
标题 :Modified cell
发明人：GRAHAM IAN; KING ANDREW
权利人:UNIV YORK
摘要:The present disclosure relates to nucleic acids that encode enzyme activities involved in the synthesis of lathyranes, intermediates in the synthesis of lathyranes and also compounds derived from lathyranes such as tiglianes, daphnanes and ingenanes; cells transformed with the nucleic acid molecules and vectors comprising the nucleic acid molecules.

专利号:US-10246688-B2
优先权日:2014-01-13
标 题 :Diterpenoid synthesis
发明人：KING ANDREW; GRAHAM IAN
权利人:UNIV YORK
摘要:The present disclosure relates to nucleic acids that encode polypeptides with cytochrome P450 activity involved in the biosynthesis of plant derived diterpenoids or diterpenes.