CAS: 27115-50-0; 2-(4-Methylbenzamido)Acetic Acid

该化合物是一种属于河马酸类的芳香化合物,其特征是,在流行酸苯环的副位置上有一个附属于流行酸苯环的甲基组,它本身就是苯酸和甘油的结合体.该化合物一般是一种白色晶状固体,由于其碳酸功能组,在水中溶解.p-甲基丙酸经常在环境化学和毒理学方面研究,因为它可以作为接触某些芳香化合物,特别是甲苯的生物标志.它在人体的代谢途径涉及同源过程,因此与...

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CAS号42469-26-1 2-(4-chloro-phe... | CAS号874-60-2 对甲基苯甲酰氯 | CAS号56-40-6 甘氨酸 | CAS号99-94-5 对甲基苯甲酸 | CAS号75152-18-0 2-p-tolyl-4H-ox... | CAS号122081-29-2 ethyl 2-[(4-met... | CAS号16352-73-1 5(4H)-Oxazolone... | CAS号16352-74-2 4-[(2-chlorophe... | CAS号122081-29-2 ethyl 2-[(4-met... | CAS号99-94-5 对甲基苯甲酸 | CAS号634148-61-1 4-(ethoxymethyl...

合成工艺路线路线简述

  • 合成目标产物 4-Methylhippuric Acid 主要起始原料 P-Toluoyl Chloride
  • (文献来源)合成步骤主要原料 P-Toluoyl Chloride
📜2--Oxazolon-(5)置于hydroxide体系中,化学反应生成4-甲基马尿酸
参考文献:Structure-Reactivity Studies On The Equilibrium Reaction Between Phenolate Ions And 2-Aryloxazolin-5-Ones: Data Consistent With A Concerted Acyl-Group-Transfer Mechanism
标题:Structure-Reactivity Studies On The Equilibrium Reaction Between Phenolate Ions And 2-Aryloxazolin-5-Ones: Data Consistent With A Concerted Acyl-Group-Transfer Mechanism
摘要:
Doi:10.1021/ja00542A028

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专利信息


专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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主要参考文献

[参考文献]: C Lacroix, Et Al. [参考文献]: J Chromatogr. 1986 Oct 31:382:275-9.
[参考文献]: G Bieniek, Et Al. Thin-Layer Chromatography Of Hippuric And M-Methylhippuric Acid In Urine After Mixed Exposure To Toluene And Xylene. Br J Ind Med. 1981 Aug;38(3):304-6.
[参考文献]: H Matsui, Et Al. High-Performance Liquid Chromatographic Separation Of Urinary Hippuric And O-, M- And P-Methylhippuric Acids With A Beta-Cyclodextrin-Bonded Column. J Chromatogr. 1989 Nov 10;496(1):189-93.
[参考文献]: I Lundberg, Et Al. Correlation Of Xylene Exposure And Methyl Hippuric Acid Excretion In Urine Among Paint Industry Workers. Scand J Work Environ Health. 1986 Apr;12(2):149-53.
[参考文献]: K J Lee, Et Al. Application Of Micellar Electrokinetic Capillary Chromatography For Monitoring Of Hippuric And Methylhippuric Acid In Human Urine. Electrophoresis. 1994 Jan;15(1):98-102.

合成参考文献


参考文献:10.1107/s1600536810035014
摘要:Fun HK, Yeap CS, Mange Y, Isloor AM, Hegde C. N-[(4-Amino-5-sulfanyl-idene-4,5-dihydro-1H-1,2,4-triazol-3-yl)meth-yl]-4-methyl-benzamide. Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 04;66(Pt 10):o2501–2.
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