CAS: 26638-43-7; Methyl 2-(Chlorosulfonyl)Benzoate

该化合物是有机合成中的一种多用途中间体,主要用于制作磺酰胺和其他含硫化合物,其活性氯磺酰胺组得以高效衍生,使其在制药和农用化学应用中具有价值;酯功能为进一步转化提供了额外的回活动;该复合物在受控条件下表现出高度纯度和稳定性,确保合成工艺的性能一致;它与一系列试剂和溶剂的兼容性增强了其在多步骤合成中的效用;妥善处理由于其湿度敏感性和潜在回活性而至关重要;适合在需要精确功能化的研究和工业环境中使用.

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CAS号7446-09-5 二氧化硫 | CAS号134-20-3 邻氨基苯甲酸甲酯 | CAS号81-08-3 2-磺基苯甲酸酐 | CAS号5459-63-2 2,2'-二硫二苯甲酸二甲酯 | CAS号67-56-1 甲醇 | CAS号34684-21-4 o-chlor°Carbony... | CAS号57683-71-3 邻甲酸甲酯苯磺酰胺 | CAS号145865-90-3 methyl 2-[[(E)-... | CAS号143850-22-0 methyl 2-but-3-... | CAS号22185-11-1 2-(N,N-二甲基氨磺酰)苯甲酸 | CAS号632-25-7 2-磺基苯甲酸 | CAS号74222-97-2 甲嘧磺隆 | CAS号74223-64-6 甲磺隆 | CAS号15448-99-4 N-甲基糖精 | CAS号145865-88-9 methyl 2-[[(E)-... | CAS号145865-87-8 methyl 2-[[(4-m...

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于二氧化硫,Copper(L) Chloride体系中,化学反应生成2-(氯磺酰基)苯甲酸甲酯
    参考文献:Meerwein Et Al.,Chemische Berichte,1957,Vol. 90,P. 841,843
    标题:Meerwein Et Al.,Chemische Berichte,1957,Vol. 90,P. 841,843

    海关参考信息

    专利信息


    专利号:US-RE29669-E
    优先权日:1973-04-23
    标 题:Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
    摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.

    专利号:US-4408058-A
    优先权日:1982-05-26
    标题 :Preparation of ortho-sulfobenzoic acid anhydride by catalyzed thermolysis
    发明人:MITCHELL III MARK L; CARR RICHARD P
    权利人:SHERWIN WILLIAMS CO
    摘要:This invention relates to a process for the synthesis of ortho-sulfobenzoic acid anhydride which comprises heating a 2-sulfohalide benzoate in the presence of a catalytic amount of a Friedel-Crafts catalyst. Especially preferred in the practice of this invention is the reaction of ortho-carbomethoxybenzenesulfonyl chloride in the presence of a zinc or iron halide to produce ortho-sulfobenzoic acid anhydride.

    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:US-3971802-A
    优先权日:1974-04-19
    标题 :Certain N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)-N-(2-thiazolyl)glycineamides
    发明人:LOMBARDINO JOSEPH G
    权利人:PFIZER
    摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.

    专利号:US-3954786-A
    优先权日:1974-04-19
    标 题 :Isoxazole intermediate compounds
    发明人:LOMBARDINO JOSEPH G
    权利人:PFIZER
    摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150°C., said products being antiinflammatory agents.

    专利号:US-3927002-A
    优先权日:1973-04-23
    标题:N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
    发明人:LOMBARDINO JOSEPH G
    权利人:PFIZER
    摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N''-alkyl-N''-(2''alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50*-150* C., said products being antiinflammatory agents.
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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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