溴甲烷,二甲基亚砜 反应生成三甲基溴化亚砜 参考文献:α-Acetoxy And α-Halomethylketones From Acyloxosulfonium Ylides 标题:α-Acetoxy And α-Halomethylketones From Acyloxosulfonium Ylides 摘要: Doi:10.1016/s0040-4039(00)76166-1
专利号:US-2012053350-A1 优先权日:2009-04-30 标题 :Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids 发明人:MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN 权利人:MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN 摘要:A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III: comprises contacting a ketosulfoxonium ylide of Formula II: with an iridium catalyst to obtain Compound III, wherein P G1 is an amine protective group; k is 0, 1, or 2; and R U , R 1 , R 2 , and R 3 are defined herein. An embodiment of the process further com rises contacting a compound of Formula I: with a sulfoxonium halide of formula (R U ) 3 S(O)Z, wherein Z is halide, in the presence of a strong base to obtain Compound II. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.
专利号:US-6737434-B2 优先权日:2000-09-22 标 题 :Imidazole derivatives or their salts 发明人:TOKIZAWA MINORU; TAKEDA SUNAO; KANEKO YASUSHI; KUSANO KOJI; ETO HIROMICHI; TACHIBANA KOICHI; SATO SUSUMU; TANIYAMA TADAYOSHI 权利人:SSP CO LTD 摘要:Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R 1 is lower alkyl; R 2 is alkyl or aralkyl; and X 1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.
专利号:WO-2013144295-A1 优先权日:2012-03-30 标题 :Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts