CAS: 24667-09-2; 4,6-Dimethyl-2-Oxo-1,2-Dihydropyridine-3-Carboxylic Acid

该化合物是一种环状环状结构的环环有机化合物,其特点是4和6个位置有2个甲基组,这增加了其独特的化学特性.分子中含有2位置的Keto组(C=O)和一个3位置的carboxylic酸组(Europe COOH),这增加了其酸性和再活动.这些功能组的存在使得它有可能成为各种化学反应的候选体,包括凝聚和替代反应.此外,该化合物可能展示生物活动,使其对药物研究感兴趣.其溶剂和环境条件不同,这对于合成和配制中应用非常重要.

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相似化合物

769-28-8 2860-55-1 38076-81-2

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上下游产品

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合成工艺路线路线简述

    📜2-氨基-4,6-二甲基-3-吡啶甲酰胺 反应生成4,6-二甲基-2-氧代-1,2-二氢吡啶-3-羧酸
    参考文献:Dornow; Neuse,Chemische Berichte,1951,Vol. 84,P. 296,300
    标题:Dornow; Neuse,Chemische Berichte,1951,Vol. 84,P. 296,300

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

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    合成参考文献


    参考文献:10.1080/14756366.2022.2070909
    摘要:Kaur S, Nieto NS, McDonald P, Beck JR, Honzatko RB, Roy A, Nelson SW. Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022 May 05;37(1):1320–6. doi: 10.1080/14756366.2022.2070909.
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