专利号:US-2012165520-A1 优先权日:2010-12-23 标题:Process for the synthesis of prodrugs of opioids 发明人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS 权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS 摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:WO-9710221-A1 优先权日:1995-09-15 标 题:Synthesis of quinazolinone libraries 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TORREY PINES INST 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-9408848-B2 优先权日:2008-08-15 标 题 :Fluorescent CDK inhibitors for treatment of cancer 发明人:YENUGONDA VENKATA MAHIDHAR; BROWN MILTON L 权利人:YENUGONDA VENKATA MAHIDHAR; BROWN MILTON L; UNIV GEORGETOWN 摘要:Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
专利号:WO-9811438-A1 优先权日:1996-09-13 标题 :Synthesis of quinazolinone libraries and derivatives thereof
专利号:CN-114702404-A 优先权日:2022-04-25 标 题 :A kind of method for promoting the synthesis of chloroprocaine impurity by microwave
[参考文献]: E H Philipson, Et Al. Fetal Acidosis, 2-Chloroprocaine, And Epidural Anesthesia For Cesarean Section. Am J Obstet Gynecol. 1985 Feb 1;151(3):322-4. [参考文献]: E H Philipson, Et Al. Intrapartum Paracervical Block Anesthesia With 2-Chloroprocaine. Am J Obstet Gynecol. 1983 May 1;146(1):16-22. [参考文献]: F Brun, Et Al. Validation Of High-Performance Liquid Chromatographic Methods On Two Silica Base-Deactivated Reversed Phases For The Determination Of Chloroprocaine And Bupivacaine. J Pharm Biomed Anal. 1996 Jun;14(8-10):1251-9. [参考文献]: G Menon, Et Al. Simultaneous Determination Of Chloroprocaine Hydrochloride And Its Degradation Product 4-Amino-2-Chlorobenzoic Acid In Bulk Drug And Injection Solutions By High-Performance Liquid Chromatography. J Pharm Sci. 1984 Feb;73(2):251-3. [参考文献]: K Krohg, Et Al. Urinary Metabolites Of Chloroprocaine Studied By Combined Gas Chromatography--Mass Spectrometry. Anesthesiology. 1981 Apr;54(4):329-32.
合成参考文献
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 摘要:J.M. Los, R.F. Rekker and C.H.T. Tonsbeek. Rec. Trav. Chim. 86, 609 (1967).