CAS: 20866-46-0; Boc-His(Boc)-Oh

相似化合物

75498-93-0 109425-51-6 123333-71-1

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号71-00-1 L-组氨酸 | CAS号645-35-2 L-组氨酸盐酸盐 | CAS号32926-43-5 N-B°C-N'-三苯甲基-L-组氨酸 | CAS号2387-23-7 N,N’-二环己基脲 | CAS号205316-11-6 N,N'-bis[Nα,Nim... | CAS号25616-02-8 B°C-his(1-b°C)-osu | CAS号870-46-2 肼基甲酸叔丁酯 | CAS号17791-52-5 B°C-组氨酸

📜二碳酸二叔丁酯置于三乙胺体系中,用 甲醇 用作溶剂,化学反应生成N,N'-二叔丁氧羰基-L-组氨酸
参考文献:1,2-Hydroxy Phosphonates And Derivatives Thereof
标题:1,2-Hydroxy Phosphonates And Derivatives Thereof
摘要:公开了式##str1##的化合物.这些化合物是肾素抑制剂,因此可用作心血管药物.

专利信息

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2023105497-A1
优先权日:2021-12-10
标题:Synthesis of glp-1 analogues
发明人：GODHA ATUL KASTURCHAND; NARAYANASWAMY SATHYA VANGANUR; BHAGYARAJ ARETI VENKATA; BAVADEKAR ASLAM JAHANGIR; LAKSHMANAPPA RUDRESH; NAGOOR SHEIKSYEDALI; MURUGAN RANJITHKUMAR; GADAKH AMOL VASANTRAO; SAMBASIVAM GANESH
权利人:ANTHEM BIOSCIENCES PVT LTD
摘要:The present invention provides a method of preparation of GLP-1 peptides by using different peptide fragments having amino acid sequences SEQ ID NO:1 (Fragment IG), SEQ ID NO:2 (Fragment SG), Fragment BG, SEQ ID NO:3, and SEQ ID NO:4 5 and combinations thereof. The method of preparation is environmentally benign, simple, straightforward, and efficient and provides the end product in high yield and purity. The purification method of the peptides is also described.

专利号:WO-2024104138-A1
优先权日:2022-11-15
标题 :N-terminal functionalization-modified cystyl dioleylamine compound, chemical synthesis method therefor, and use thereof
发明人：YANG ZHENJUN; GUO HUA; ZHU YUEJIE; YU JING; HONG JIAMEI
权利人:UNIV BEIJING
摘要:Disclosed herein are an N-terminal functionalization-modified cystyl dioleylamine compound, a chemical synthesis method therefor, and use thereof. A central skeleton of the compound is cystine; a cystine carboxyl terminal is modified with oleylamine to form a double hydrophobic tail chain structure; an amino terminal is modified with a functionalized hydrophilic head including an amino acid with a positive electricity center or an aromatic ring structure and a polypeptide fragment. A structural general formula is as shown below. The cystine central skeleton structure comprises a disulfide bond, such that the molecule has a reduction-sensitive property, and an overall structure of the hydrophobic tail chain and the hydrophilic head of the molecule determines that the molecule is amphipathic and can be self-assembled in water and other systems. A cationic charge center comprised in the hydrophilic head can form an electrical effect with a target nucleic acid so as to encapsulate the nucleic acid, thereby playing a role in nucleic acid delivery. The N-terminal functionalization-modified cystyl dioleylamine compound provided by the present invention, as a novel lipid material or an auxiliary lipid material, can efficiently deliver a nucleic acid compound into a cell, and has huge potential in the field of gene therapy.

专利号:US-2004006203-A1
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds

专利号:US-3592836-A
优先权日:1966-12-23
标 题:Aryloxycarbonyl fluorides and amino acids and their production
发明人：UGI IVAR; KLAUKE ERICH; SCHNABEL EUGEN; HOFFMANN PETER
权利人:BAYER AG
摘要:ARYLOXYCARBONYL FLUORIDES SUCH AS FURFURYLOXYCARBONYL-, P-METHOXYBENZYLOXYCARBONYL- AND TRIMETHOXYBENZYLOXYCARBONYL-FLUORIDES ARE PROVIDED WHICH ARE USEFUL AS INTERMEDIATES FOR AMINO ACID DERIVATIVES AND ARE OBTAINED FROM CARBONYL-FLUORIDE CHLORIDE BY REACTION WITH THE APPROPRIATE ALCOHOL. THE AMINO ACID DERIVATIVES OF SUCH CARBONYL-FLUORIDES ARE BUILT UP THROUGH ACYLATION OF AMINO ACIDS THEREWITH. THESE AMINO ACID DERIVATIVES ARE USEFUL AS INTERMEDIATES FOR THE SYNTHESIS OF POLYPEPTIDES. THE REACTION OF CARBONYLCHLORIDE-FLUORIDE IS ADVANTAGEOUSLY CARRIED OUT AT TEMPERATURES OF 0 TO 70*C. IN AN INERT SOLVENT AND IN THE PRESENCE OF AN ACID-BINDING AGENT. THE AMINO ACID DERIVATIVES ARE FORMED AT TEMPERATURES BETWEEN +20 AND -20*C. ALSO IN THE PRESENCE OF AN ACID-BINDING AGENT. IMINO ACIDS CAN BE USED IN PLACE OF AMINO ACIDS. THE AMINO- OR IMINO-ACID DERIVATIVES OR ESTERS ARE ADVANTAGEOUSLY PREPARED AT CONSTANT. CONTROLLED PH VALUES, PREFERABLY BY THE USE OF AUTOMATIC PH CONTROL EQUIPMENT.