CAS: 20074-80-0; 5-Chloropentanal

该化合物是有机化合物,其特点是甲状腺功能组和五碳直链烷第五碳的氯替代体,其分子式为C5H9ClO,表明存在5个碳原子,9个氢原子,1个氯原子和1个氧原子.该化合物一般是无色的黄色液体,有独特的气味.由于存在甲状腺体,可溶于有机溶剂,并表现出温和的再活动,可参与各种化学反应,包括氧化和凝聚.氯原子引入了额外的再活性,使其成为有机合成的有用中间体,特别是在制药和农用化学的准备中.安全考虑包括在通风良好的地区处理它,并使用适当的个人防护设备,因为它在接触时可能构成健康风险.

结构式图片

相似化合物

6280-87-1 1119-46-6 5259-98-3

欧盟法规

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合成工艺路线路线简述

  • 合成目标产物 5-Chloropentanal 主要起始原料 5-Chloropentyl Acetate
  • (文献来源)合成步骤主要原料 5-Chloropentyl Acetate
📜5-氯戊腈置于二异丁基氢化铝体系中,用 正己烷,二氯甲烷 用作溶剂,化学反应 1.0H,以49%的收率获得5-氯戊醛
参考文献:Studies In Biomimetic Alkaloid Syntheses. 6. Alternative Pathways To Secodines And Their Acyclic Enamino Acrylate Analogs. Total Syntheses Of Desethylibophyllidine,D-Norvincadifformine,Desethylvincadifformine,20-Methyldesethylvincadifformine,And 3-Oxovincadifformine
标题:Studies In Biomimetic Alkaloid Syntheses. 6. Alternative Pathways To Secodines And Their Acyclic Enamino Acrylate Analogs. Total Syntheses Of Desethylibophyllidine,D-Norvincadifformine,Desethylvincadifformine,20-Methyldesethylvincadifformine,And 3-Oxovincadifformine
摘要:
Doi:10.1021/jo00323A007

海关参考信息

专利信息


专利号:US-4220774-A
优先权日:1978-10-26
标 题:Vincadifformine synthesis process
发明人:KUEHNE MARTIN E
权利人:OMNIUM CHIMIQUE SA
摘要:The preparation of vincadifformine and some derivatives thereof for use as a starting material for synthesis of the corresponding vincamine derivatives or for synthesis of bisindole alkaloids having clinically important antitumor properties.

专利号:US-2003040639-A1
优先权日:1999-12-30
标题:Method for the preparation of substituted benzene derivatives
发明人:RUHLAND THOMAS; ROTTLANDER MARIO; ANDERSEN KIM
权利人:LUNDBECK & CO AS H
摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.

专利号:WO-9425423-A1
优先权日:1993-04-26
标题:Asymmetric synthesis of chiral secondary alcohols

专利号:WO-0149681-A1
优先权日:1999-12-30
标题 :A method for the preparation of substituted benzene derivatives
发明人:RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM
权利人:LUNDBECK & CO AS H; RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM
摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.

专利号:EP-0956286-B1
优先权日:1997-02-04
标 题:Synthesis of terfenadine and derivatives

专利号:EP-0956286-A1
优先权日:1997-02-04
标 题:Synthesis of terfenadine and derivatives

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1055/s-0039-1690834
摘要:Antonsen S, Monsen EB, Ovchinnikov K, Nolsøe JMJ, Ekeberg D, Kristiansen JE, Diep DB, Stenstrøm Y. Synthesis of the Enantiomers of Thioridazine. SynOpen. 2020 Jan;04(01):12–6. doi: 10.1055/s-0039-1690834.
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