CAS: 18956-15-5; (E)-1-(2,6-Dihydroxy-4-Methoxyphenyl)-3-Phenylprop-2-En-1-One

上下游产品

CAS号1036-72-2 5,7-二甲氧基黄烷酮 | CAS号75291-74-6 (±)- 乔松酮 | CAS号75291-74-6 (±)- 乔松酮

📜Pinostrobin置于氢氧化钾体系中,用 甲醇 用作溶剂,化学反应生成2',3'-二羟基-4'-甲氧基查耳酮
参考文献:类黄酮:对乳腺癌细胞抗增殖活性的结构要求.
标题:类黄酮:对乳腺癌细胞抗增殖活性的结构要求.
摘要:研究了在a环上具有各种取代基的几类类黄酮(类黄酮,黄烷酮,2'-羟基查耳酮和黄烷-4-醇)对mcf-7人乳腺癌细胞的抗增殖活性.讨论了这些化合物的构效关系.发现2'-羟基查耳酮和甲氧基黄酮是mcf-7细胞生长的有效抑制剂,而黄酮和flavan-4-Ols除7,8-二羟基黄酮外似乎是弱抑制剂.
Doi:10.1016/s0960-894X(01)00617-5

专利信息

专利号:US-7851654-B2
优先权日:2006-04-03
标题 :Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof
发明人：PARK KI HUN; KIM JIN HYO; SEO WOO DUCK; RYU YOUNG BAE; RYU HYUNG WON; LEE WOO SONG; GAL SANG WAN
权利人:IND ACADEMIC COOP
摘要:Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.