4-溴异丙苯 以63%的收率获得4-异丙基苯基硼酸 参考文献:N-Aryl Thienyl-,Furyl-,And Pyrrolyl-Sulfonamides And Derivatives Thereof That Modulate The Activity Of Endothelin 标题:N-Aryl Thienyl-,Furyl-,And Pyrrolyl-Sulfonamides And Derivatives Thereof That Modulate The Activity Of Endothelin 摘要:提供了噻吩基,呋喃基和吡咯基磺酰胺以及用于调节或改变内皮素肽家族活性的方法.特别是,提供了n-(异恶唑基)噻吩磺酰胺,N-(异恶唑基)呋喃磺酰胺和n-(异恶唑基)吡咯磺酰胺以及使用这些磺酰胺通过将受体与磺酰胺接触来抑制内皮素肽与内皮素受体结合的方法.还提供了通过施用有效量的一个或多个这些磺酰胺或其前药来治疗内皮素介导的疾病的方法,这些磺酰胺或其前药抑制或增加内皮素的活性.
专利号:US-12187735-B2 优先权日:2018-09-17 标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-2025092058-A1 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease 发明人:LING XIANG; LI QINGYONG; LI FENGZHI 权利人:CANGET BIOTEKPHARMA LLC 摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.
专利号:US-10273339-B2 优先权日:2006-02-24 标题 :Synthesis of a highly crystalline, covalently linked porous network
专利号:CN-110698399-A 优先权日:2019-10-24 标题 :A kind of palladium-catalyzed synthesis of aryl acridine derivative and preparation method thereof
专利号:CN-113402412-A 优先权日:2021-06-10 标题 :(E) Synthesis of β-fluoroacrylamide derivatives
专利号:WO-2020061106-A2 优先权日:2018-09-17 标 题 :Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease
参考文献:10.1055/s-0035-1562499 摘要:Wu X, Yan G, Lou J. Metal-Free, DTBP-Mediated Methylthiolation of Arylboronic Acids with Dimethyldisulfide. Synlett. 2016 Jun 27;27(15):2269–73. doi: 10.1055/s-0035-1562499. 参考文献:10.1007/s12274-023-5605-2 摘要:Chang X, Huang L, Gao Y, Fu Y, Ma J, Yang H, Liu J, Fu X, Lin X, Feng X, Du S, Gao H. On-surface synthesis and edge states of NBN-doped zigzag graphene nanoribbons. Nano Res. 2023 Mar 26;16(7):10436–42. doi: 10.1007/s12274-023-5605-2.