CAS: 13574-13-5; Boc-Glu(Obzl)-Oh

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CAS号1676-73-9 L-谷氨酸-γ-苄酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号132090-12-1 B°C-Glu(OBn)-OAll | CAS号13574-84-0 2-异丁吲哚丁醇 | CAS号617-65-2 DL-谷氨酸 | CAS号104-15-4 对甲苯磺酸 | CAS号100-51-6 苯甲醇 | CAS号56-86-0 L-谷氨酸 | CAS号100-39-0 溴化苄 | CAS号3190-71-4 谷氨酸 5-苄酯 N-羧基环内酸酐 | CAS号59587-94-9 B°C-L-谷氨酸-1-苯酯 | CAS号56-86-0 L-谷氨酸 | CAS号18800-74-3 4-叔丁氧羰基氨基-4-氨基甲酰基丁酸 | CAS号24277-39-2 B°C-L-谷氨酸-1-叔丁酯 | CAS号2419-94-5 B°C-L-谷氨酸 | CAS号32886-40-1 B°C-Glu(OBzl)-OSu | CAS号72086-72-7 N-叔丁氧羰基-L-谷氨酸1-甲酯 | CAS号59279-58-2 B°C-L-谷氨酸(苄酯)-1-甲酯 | CAS号218943-30-7 B°C-β-HomoGlu(O...

L-谷氨酸置于硫酸,三乙胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成N-叔丁氧羰基-L-谷氨酸 5-苄酯
参考文献:设计和合成环状伪二肽的所有非对映异构体,以模拟环状cxcr4五肽拮抗剂.
标题:设计和合成环状伪二肽的所有非对映异构体,以模拟环状cxcr4五肽拮抗剂.
摘要:2,5-双[(3-胍基)丙基]-1-[3-(4-羟苯基)丙酰基]-7-(2-萘乙酰基)-1,4,7-三氮杂环十一烷基-9-En的四种非对映异构体-3-One(-)和2,5-双[(3-胍基)丙基]-1-(4-羟基苯基乙酰基)-7-(2-萘基乙酰基)-1,4,7-三氮杂环十一烷基-9-En通过发散的方法从i-和d-谷氨酸合成-3-一个(-).通过线性双(烯丙基胺)的闭环复分解反应制得11元环核,并使用双(boc)胍通过同时的两次mitsunobu反应引入胍基官能团.设计这些化合物以模拟环状五肽fc131(c [gly-D-Tyr-Arg-Arg-Nal]).
Doi:10.1039/b702649H

专利信息

专利号:US-2007179279-A1
优先权日:2005-12-30
标题:Methods for the synthesis of arginine-containing peptides
发明人：CHEN LIN; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

专利号:US-12060315-B2
优先权日:2019-02-14
标 题:Production processes of S- and O-diacylated gamma-glutamyl-cysteamine prodrugs
发明人：ANDERSON ROSALEEN JOY; FROST LISA; BARNWELL NEIL; LEVICK MATTHEW; HALES IVAN; DUNN MICHAEL
权利人:UNIV OF SUNDERLAND
摘要:Methods are provided for the synthesis of a compound of formula (X). R 2 is selected from —H, —C 1 -C 4 -alkyl, —C 2 -C 4 -alkenyl and C 1 -C 4 -aryl; R 3 is selected from —C(O)H and —C(O)C 1 -C 4 -alkyl; and A is a pharmaceutically acceptable anion (e.g. a halide). Also provided are intermediate compounds formed during the synthesis.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2023148764-A1
优先权日:2022-02-01
标 题 :Novel cholic acid derivatives for the treatment and prevention of autoimmune diseases and uses thereof
发明人：AWASTHI AMIT; SALUNKE DEEPAK; DALAL RAJDEEP; MADAN UPASNA; SADHU SRIKANT; SINGLA POONAM; KAMBOJ AARZOO; ASTHANA SHAILENDRA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; PANJAB UNIV
摘要:The present invention is to design and develop novel synthetic cholic acid derivatives for treating autoimmune disorders/inflammatory conditions, process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-4212795-A
优先权日:1978-11-13
标题:Cyclization of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-4772587-A
优先权日:1985-04-16
标题:Dipeptide derivative of fatty acid
发明人：TANAKA TAKAHARU; HIGUCHI NAOKI; SAITOH MASAYUKI; HASHIMOTO MASAKI
权利人:SUNTORY LTD
摘要:A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.