CAS: 125620-16-8; 3-(1H-1,2,3,4-Tetrazol-1-yl)Phenol

该化合物是一种杂交循环化合物,其成分是连接四氯联苯的酚组,在合成化学中具有独特的再活性和多功能性.四甲环增强了其作为碳酸的生物活性,使其在制药和农用化学应用中具有宝贵价值.其苯丙基氢氧基组提供了其他功能化场所,能够进一步衍生.该化合物在一系列条件下表现出稳定性,便于在混合反应中使用,并成为复杂分子结构的建筑块.其双重功能使其在药用化学中特别有用,用于设计具有更好的代谢稳定性和结合性的生物活性分子.

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832739-85-2 14213-13-9 25108-32-1

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    CAS号122-51-0 原甲酸三乙酯 | CAS号591-27-5 间氨基苯酚

    合成工艺路线路线简述

      📜间羟基苯甲醛置于sodium Azide体系中,用 甲醇 用作溶剂,化学反应 8.0H,以81%的收率获得3-四唑-1-基-苯酚
      参考文献:Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst For The Synthesis Of Tetrazoles Under Visible Light Irradiation
      标题:Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst For The Synthesis Of Tetrazoles Under Visible Light Irradiation
      摘要:Herein,A Polymer Supported Fe-Phthalocyanine Entangled With Carboxyl Functionalized Benzimidazolium Moiety (Psfepccfbm) Explored As Heterogenous Photocatalyst,For Regioselective Synthesis Of 1H-Tetrazoles From Sodium Azide And Other Affordable Substrates. The Psfepccfbm Displayed Good To Excellent Yield Of The Product (79-91%) Under Visible Light (5 W) Irradiations Using Home-Made Photoreactor. The Nan3 Acts As A Nitrogen Donor Of Tetrazoles Ring As Well As It Convert Aldehyde Into Isocyanide As One Of The Nitrogen Sources. The Catalyst Could Be Recycled Up To 5Th Run Successfully Without Altering Its Catalytic Activity. The Small Amount Of The Catalyst Loading,Extensive Substrate Range,Ease Of Separation Of The Catalyst By Simple Filtration,Less Reaction Time,Simple Workup Procedure,And Excellent Product Yield Are The Salient Features Of The Investigated Protocol.
      Doi:10.1007/s10562-020-03461-Z

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      主要参考文献

      参考标题:Building Heterocyclic Systems With Rc(Or)2+ Carbocations In Recyclable Brønsted Acidic Ionic Liquids: Facile Synthesis Of 1-Substituted 1H-1,2,3,4-Tetrazoles, Benzazoles And Other Ring Systems With Ch(Oet)3 And Etc(Oet)3 In [etnh3][no3] And [pmim(So3H)][o
      作者:Gopalakrishnan Aridoss,Kenneth K. Laali |发布日期:2011.5
      摘要:Il-1/ch(Oet) 3 . The Latter Was Also Formed From 2-Aminobenzoic Acid In Il-1/ch(Oet) 3 . Mechanistic Implications Are Addressed. The Reported Protocols Enable Rapid Assembly Of A Host Of Heterocyclic Systems In High Yields With The Added Advantage Of Recycling And Reuse Of The Ils.

      合成参考文献


      参考文献:10.1055/s-0040-1719852
      摘要:Laali KK, Kalkhambkar RG, Sutar SM. Recent Advances in the Synthesis of Diverse Libraries of Small-Molecule Building Blocks in Ionic Liquids (ILs). Synlett. 2021 Nov 18;33(07):617–36. doi: 10.1055/s-0040-1719852.
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