CAS: 122306-01-8; (6-Bromopyridin-3-yl)Methanol

相似化合物

149806-06-4 6311-35-9 26218-78-0

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6-bromonicotinic acid 6-bromonicotinaldehyde 2-bromo-5-bromomethylpyridine 2-bromonicotinic acid 2-bromo-5-[(trityloxy)methyl]pyridine 5-(hydroxymethyl)-2-(prop-1-ynyl)pyridine 2-prop-1-ynyl-5-trityloxymethyl-pyridine 2-((E)-2-Iodo-propenyl)-5-trityloxymethyl-pyridine

2-溴-5-醛基吡啶置于sodium Tetrahydroborate体系中,化学反应生成6-溴-3-羟甲基吡啶
参考文献:吡啶肼的硫代酰胺衍生物的hen和es配合物,与淀粉样β斑块结合.
标题:吡啶肼的硫代酰胺衍生物的hen和es配合物,与淀粉样β斑块结合.
摘要:与年龄相关的脑血管淀粉样β沉积(一种称为脑淀粉样血管病)可导致中风和痴呆.这项研究旨在设计与淀粉样蛋白β斑块结合的新型放射性tech 99 M复合物,这些复合物具有使用单光子发射计算机断层扫描(spect)成像来辅助诊断脑淀粉样蛋白血管病的潜力.制备了六个新的含有苯并呋喃或苯乙烯基吡啶基官能团的吡啶基硫代氨基脲化合物,已知这些基团选择性结合淀粉样蛋白斑.Not的非放射性同位素不可用,因此used被用作探索化学的替代物.新的配体用于制备定义明确的[re-Oxo] 3+络合物,其中两个吡啶基硫代氨基脲化合物配体与单个金属离子配位,得到带有两个淀粉样β靶向功能基团的二价络合物.研究了[re-Oxo] 3+配合物与合成淀粉样蛋白-β1-42和淀粉样蛋白斑在人脑组织中的相互作用.选择了两个配体来开发在示踪剂水平上制备其[99Mtc-Oxo] 3+复合物的方法.这些99 99 M配合物可能与其thei
Doi:10.1007/s00775-018-1590-4

专利信息

专利号:US-6416861-B1
优先权日:1999-02-16
标题 :Organosilicon compounds and uses thereof
发明人：LEE YOUNGHEE; SILVERMAN RICHARD B
权利人:UNIV NORTHWESTERN
摘要:A compound of the formula: n and a resin-bound compound of the formula: n and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 1 , P, Ar 1 , and X are as herein defined.

专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:RU-2113437-C1
优先权日:1991-10-24
标 题:Substituted pyrimidines or their pharmaceutically acceptable salts, or n-oxides, methods of their synthesis and pharmaceutical composition based on thereof