CAS: 931117-61-2; (S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)-2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid Hydrochloride

英文名称(S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)-2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid Hydrochloride
中文名称利伐沙班杂质25
IUPAC名称(S)-2-(2-((4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic acid hydrochloride
其它别名Rivaroxaban-17; Rivaroxaban Impurity 24/(S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)- 2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid Hydrochloride; Rivaroxaban Impurity P: Rivaroxaban Hydrochloride Hydrochloride; (S)-2-(2-((4-(5-((5-Chlorothiophene-2-Carboxamido)Methyl)- 2-Oxooxazolidin-3-yl)Phenyl)Amino)Ethoxy)Acetic Acid Hydrochloride; 2-[2-[[4-[(5S)-5-[[[(5-Chloro-2-Thienyl)Carbonyl]Amino]Methyl]-2-Oxo-3-Oxazolidinyl]Phenyl]Amino]Ethoxy]-Acetic Acid Hydrochloride; Rivaroxaban Impurity A Hydrochloride; Rivaroxaban Impurities25
CAS编号931117-61-2
MFCD编号:MFCD30741720
FDA UNII编号:NB5DEY8WUQ
分子式:C19H21Cl2N3O6S分子量:490.36
产品CID: 1969852
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: UFNIIYAHXMBQSV-UQKRIMTDSA-N
InChI=1S/C19H20ClN3O6S.ClH/c20-16-6-5-15(30-16)18(26)22-9-14-10-23(19(27)29-14)13-3-1-12(2-4-13)21-7-8-28-11-17(24)25;/h1-6,14,21H,7-11H2,(H,22,26)(H,24,25);1H/t14-;/m0./
计算化学: 氢键受体数8.0氢键供体数4.0可旋转键数10.0

MSDS等安全信息

上下游产品

Rivaroxaban 2-{2-[1-(5-chlorothiophen-2-yl)-N-{4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}formamido]ethoxy}acetic acid 2-[2-({4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}amino)ethoxy]acetic acid

合成工艺路线路线简述

366789-02-8 = 931117-61-2
反应条件:1.1 Reagents: Hydrochloric Acid,Water Solvents: Acetic Acid,Water; Rt; Rt -> 70 °C; 5 - 6 H,70 °C; 70 °C -> Rt; 15 H,Rt
标题:Preparation Of 2-Aminoethoxyacetic Acid Derivatives As Factor Xa Inhibitors For Treating Thromboembolic Diseases
参考文献:Germany

📜利伐沙班置于盐酸,水,溶剂黄146体系中,化学反应 6.0H,以76%的收率获得产物利伐沙班杂质25
参考文献:2-Aminoethoxyacetic Acid Derivatives And Their Use
标题:2-Aminoethoxyacetic Acid Derivatives And Their Use
摘要:本申请涉及新型2-氨基乙氧基乙酸衍生物,其制备方法,其用于治疗和/或预防疾病以及用于制备用于治疗和/或预防疾病的药物,特别是血栓栓塞性疾病的用途.