CAS: 916975-92-3; 4-Methyl-1-(3-Nitro-5-(Trifluoromethyl)Phenyl)-1H-Imidazole

相似化合物

641571-11-1 917391-29-8 351324-52-2

上下游产品

CAS号822-36-6 4-甲基咪唑 | CAS号401-99-0 3,5-二硝基三氟甲苯 | CAS号630125-49-4 3-溴-5-硝基三氟甲苯 | CAS号454-73-9 3-氟-5-硝基三氟甲苯 | CAS号641571-11-1 3-(4-甲基-1H-咪唑-1...

📜三氟甲苯置于8-羟基异喹啉,Copper(L) Iodide,硫酸,溴,硝酸,Potassium Carbonate,三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 27.0H,反应生成 4-甲基-1-(3-硝基-5-三氟甲基-苯基)-1H-咪唑
参考文献:Method For Preparing Nilotinib Intermediate
标题:Method For Preparing Nilotinib Intermediate
摘要:本发明公开了一种制备尼洛替尼中间体3-(4-甲基-1H-咪唑-1-基)-5-三氟甲基苯胺(I)的方法.该方法包括以下步骤:以三氟甲基甲苯为原料,通过硝化,溴化,缩合和还原依次制备尼洛替尼中间体(I).与现有技术相比,该制备方法具有以下优点:产率相对较高,原材料易获得,工艺简洁,副反应少,适合工业生产,促进了大宗药物的经济技术发展.

专利信息

专利号:US-7709657-B2
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds
发明人：ACEMOGLU MURAT; SCHENKEL BERTHOLD; SHIEH WEN-CHUNG; XUE SONG; WIDMER ERICH; GARCIA FUENTES PEDRO; MARTIN MEDINA JOSE; VICENTE BANOS FRANCISCO
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-11414388-B2
优先权日:2018-04-10
标 题:Crystal form of 3-(4-methyl-1h-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and use thereof
发明人：NIU DELIANG; MA BOJUN; ZHU ZHANQUN; WAN QIANG
权利人:ARIZEST SHANGHAI PHARMATECH CO LTD; JIANGSU XIDI PHARMACEUTICALS CO LTD; SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP CO LTD
摘要:The present invention relates to a crystal form of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and the use thereof. Specifically, disclosed are a crystal form A of a monohydrochloride anhydrous substance of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride, a method for preparing the crystal form A and the use of the crystal form in the synthesis of nilotinib. The crystal form A of the present invention has good stability and purity, and can be directly used in the preparation and production of nilotinib. The method for preparing nilotinib in the present invention is easy to operate and has high industrial application value.

专利号:US-8008504-B2
优先权日:2005-06-09
标题 :Process for the synthesis of organic compounds
发明人：ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-2008200692-A1
优先权日:2005-06-09
标 题:Process For the Synthesis of Organic Compounds

专利号:ES-2465522-T3
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds

专利号:CA-2611280-A1
优先权日:2005-06-09
标题 :Processes for the synthesis of 5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine and its intermediates