CAS: 88767-98-0; Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate

该化合物是一个化学化合物,以其酯分功能组为特征,该化合物来自丁酸和酒精酒精混合物;该化合物具有三氟硫磺基混合物,该化合物可增强该物质的再活性和可溶性;该混合物的存在有助于其芳香特性,有可能影响其相互作用和稳定性;该混合物的配置表明一种特定的立体化学特征,该化合物可影响该化合物的生物活动以及与其他分子的相互作用;乙基(R)-4-苯-2-[(三氟甲基)硫基]氧基丁酸通常用于合成有机化学,可作为生产药物或农用化学溶剂的中间体;该混合物独特的结构特征使其在药物开发和化学合成方面的研究中具有兴趣;应当参考安全数据,以便处理和使用该化合物,因为含有三氟基化合物的化合物具有特定的毒性特性.

英文名称Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate
中文名称(R)-4-苯基-2-[[(三氟甲基)磺酰基]氧基]丁酸乙酯
IUPAC名称ethyl (R)-4-phenyl-2-(((trifluoromethyl)sulfonyl)oxy)butanoate
其它别名Ethyl (2R)-4-Phenyl-2-(Trifluoromethanesulfonyloxy)Butanoate; C13H15F3O5S; Ethyl (2R)-4-Phenyl-2-(Trifluoromethylsulfonyloxy)Butanoate; Ethyl (R)-4-Phenyl-2-((Tr
CAS编号88767-98-0
MFCD编号:MFCD09751096
分子式:C13H15F3O5S
分子量:340.32
产品CID: 1908024
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: UDJNHUAEPSYCRU-LLVKDONJSA-N
InChI=1S/C13H15F3O5S/c1-2-20-12(17)11(21-22(18,19)13(14,15)16)9-8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m1/s1…
计算化学: 氢键受体数5.0氢键供体数0.0可旋转键数7.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

上下游产品

合成工艺路线路线简述

合成目标产物 Ethyl (R)-4-Phenyl-2-[[(Trifluoromethyl)Sulfonyl]Oxy]Butyrate 主要起始原料 (R)-2-Hydroxy-4-Phenylbutyric Acid
90315-82-5 + 358-23-6 = 88767-98-0
反应条件:1.1 Reagents: 2,6-Lutidine Solvents: Dichloromethane; Rt -> -78 °C; 2 H,-78 °C1.2 Solvents: Water
标题:Preparation Of 3,5-Methanobenzo[b]Azepines: A Sp3-Rich Quinolone Isostere
作者:Herter,Loic; Perrin,Timothe; Fessard,Thomas; Salome,Christophe
参考文献:Organic Letters 日期:2023 卷标:25(33) 页码:6161-6166]

90315-82-5 = 88767-98-0
反应条件:1.1 Reagents: Pyridine,Trifluoromethanesulfonic Anhydride Solvents: Dichloromethane
标题:The Design And Synthesis Of The Angiotensin-Converting Enzyme Inhibitor Cilazapril And Related Bicyclic Compounds
作者:Attwood,Michael R.; Hassall,Cedric H.; Krohn,Antonin; Lawton,Geoffrey; Redshaw,Sally
参考文献:Journal Of The Chemical Society 日期:1986 卷标:(6) 页码:1011-19]

90315-82-5 = 88767-98-0
反应条件:1.1 Reagents: Pyridine,Trifluoromethanesulfonic Anhydride Solvents: Dichloromethane
标题:Angiotensin-Converting Enzyme Inhibitors. Perhydro-1,4-Thiazepin-5-One Derivatives
作者:Yanagisawa,Hiroaki; Ishihara,Sadao; Ando,Akiko; Kanazaki,Takuro; Miyamoto,Shuichi; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1987 卷标:30(11) 页码:1984-91]

90315-82-5 + 358-23-6 = 88767-98-0
反应条件:1.1 Reagents: 2,6-Lutidine Solvents: Dichloromethane; -78 °C; 2 H,-78 °C1.2 Solvents: Water
标题:Preparation Of 3,5-Methanobenzo[b]Azepines: A Novel Sp3-Rich Quinolone Isostere
作者:Herter,Loic; Fessard,Thomas; Salome,Christophe
参考文献:Chemrxiv 日期:2023 卷标:1 页码:1-5]

120999-41-9 = 88767-98-0 [标题:Reaction Conditions
标题:Enantioselevtive Synthesis Of N-[(S)-Ethoxycarbonyl-3-Phenylpropyl]-L-Alanyl-L-Proline From Chiral Synthon Prepared Enzymatically; A Practical Method For Large-Scale Synthesis
作者:Tseng,Tsung Chin; Duo,Tsai Hui; Wang,Yi Fong
参考文献:Journal Of The Chinese Chemical Society (Taipei 日期:1991 卷标:38(5) 页码:487-90

(R)-2-羟基-4-苯基丁酸置于2,6-二甲基吡啶,硫酸体系中,用二氯甲烷作为反应溶剂,化学反应 4.0H,反应生成 (R)-1-(乙氧羰基)-3-苯基丙基三氟甲磺酸酯
参考文献:3,5-亚甲基苯并[b]氮杂卓的制备:富含 Sp3 的喹诺酮电子等排体
标题:3,5-亚甲基苯并[b]氮杂卓的制备:富含 Sp3 的喹诺酮电子等排体
摘要:用饱和生物等排体取代生物活性化合物中的芳环已成为获得具有改善的物理化学特征的新颖结构的流行策略.在本文中,我们描述了 3,5-亚甲基苯并[B]氮杂卓类似物的有效合成,并建议将它们作为喹诺酮类的电子等排体.喹诺酮类是杂芳族扁平环,被认为是特殊的支架.该支架的等排版本具有更多 3D 特征,将为扩展其用途提供新的选择.
DOI:10.1021/acs.Orglett.3C02250

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4801721-A
优先权日:1984-08-16
标题 :Stereospecific synthesis of carboxyalkyl peptides
发明人：RYAN JAMES W; CHUNG ALFRED
权利人:RYAN JAMES W; CHUNG ALFRED
摘要:Methods for the alkylation of substituted amines with trifluorate esters is disclosed.

专利号:CN-109438449-B
优先权日:2018-11-16
标题:Synthesis method of cilazapril containing hexahydropyridazine acid structure

专利号:US-10633329-B2
优先权日:2016-11-17
标题 :Method for preparing lisinopril intermediate
发明人：WANG SONGQING; DONG PENG; ZHENG YANG; LI QUANJUN
权利人:ZHEJIANG HUAHAI PHARM CO LTD; ZHEJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD; ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO LTD; ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO LTD
摘要:A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N 2 -[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N 6 -trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.