CAS: 68724-11-8; 1-((2-Hydroxyethoxy)Methyl)-5-Methylpyrimidine-2,4(1H,3H)-Dione

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1,2-dihydro-5-methyl-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine methyl>-5-methyluracil1-2-(benzoyloxy)ethoxymethyl-5-methyluracil thymine1-(2-acetoxyethoxy)methylthymine (2-benzoyloxyethyl)oxymethyl chloride 5-methyl-1-(2'-O-p-tolylsulfonylethoxymethyl)uracil B°C-Glu(acyclothymidine ester)-OBn 2-[(5-methyluracil-1-yl)methoxy]-ethyl N-[(benzyloxy)carbonyl]-L-valinate ethoxy>methyl>thymine6-(1-acetoxy-1-phenylmethyl)-1-2-(tert-butyldimethylsilyl)oxyethoxymethylthymine

📜O,O-二(三甲基甲硅烷基)胸苷置于sodium体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 1-(2-羟基乙氧基)甲基-5-甲基尿嘧啶
参考文献:Nucleic Acid Related Compounds. 37. Convenient And High-Yield Syntheses Of N-[(2-Hydroxyethoxy)Methyl] Heterocycles As "Acyclic Nucleoside" Analogues
标题:Nucleic Acid Related Compounds. 37. Convenient And High-Yield Syntheses Of N-[(2-Hydroxyethoxy)Methyl] Heterocycles As "Acyclic Nucleoside" Analogues
摘要:1,3-二氧杂环戊烷与乙酰溴反应,得到(2-乙酰氧乙氧基)溴甲烷(2A),收率为88%.多种嘧啶和三种氯代嘌呤经过三甲基硅基化处理后与2A偶联.相应的n-1和n-9烷基化产物(收率为79-89%)经去乙酰化处理后得到n-[(2-羟基乙氧基)甲基]杂环化合物.2-氨基-6-取代嘌呤衍生物的6-氨基或6-氯取代基经过腺苷脱氨酶顺利水解,得到9-[(2-羟基乙氧基)甲基]鸟苷(无环鸟苷),这是一种有效的抗病毒药物.
DOI:10.1139/v82-081