CAS: 63407-54-5; (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(Phenethylthio)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是一种化学定义的硫基硅酸盐衍生物,具有苯乙基替代成分,在厌食位置上具有立体化学特性,其定义明确的配置确保了再活性的一致性,特别是在同步和衍生研究方面.该化合物的氢氧基化合物组提供了多种进一步功能化的场所,使它成为碳水化合物化学的多功能中间体.苯乙基乙基酸会增强稳定性,同时保留选择性的裂痕,对保护群体战略有用.其结构特征有利于在寡头树脂组,玻璃合成和药用化学研究中合成应用.该化合物的纯和立体化学精度支持在机械研究和酶学研究中可产生再生效果.

结构式图片

相似化合物

7473-36-1 13533-58-9 74590-47-9

合成工艺路线路线简述

    Alkaline Earth Salt Of/The/ Methylsulfuric Acid 在 甲醇,Sodium Methylate体系中,获得 2-Phenylethyl β-D-Thiogalactoside
    参考文献:Helferich; Tuerk,Chemische Berichte,1956,Vol. 89,P. 2215,2218
    标题:Helferich; Tuerk,Chemische Berichte,1956,Vol. 89,P. 2215,2218

    海关参考信息

    专利信息


    专利号:US-9925504-B2
    优先权日:2004-03-31
    标 题 :Compartmentalised combinatorial chemistry by microfluidic control
    发明人:GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME
    权利人:GRIFFITHS ANDREW; WEITZ DAVID; AHN KEUNHO; LINK DARREN; BIBETTE JEROME; HARVARD COLLEGE; MEDICAL RES COUNCIL
    摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.
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    [参考文献]: Amy B Banta, Et Al. Key Features Of σs Required For Specific Recognition By Crl, A Transcription Factor Promoting Assembly Of Rna Polymerase Holoenzyme. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15955-60.
    [参考文献]: Bamaprasad Dutta, Et Al. Profiling Of The Chromatin-Associated Proteome Identifies Hp1Bp3 As A Novel Regulator Of Cell Cycle Progression. Mol Cell Proteomics. 2014 Sep;13(9):2183-97.
    [参考文献]: Eric Kim, Et Al. Long-Term Imaging Of Caenorhabditis Elegans Using Nanoparticle-Mediated Immobilization. Plos One. 2013;8(1):E53419.
    [参考文献]: Luba A Aleksandrov, Et Al. Thermal Stability Of Purified And Reconstituted Cftr In A Locked Open Channel Conformation. Protein Expr Purif. 2015 Dec:116:159-66.
    [参考文献]: Machteld M Tiemessen, Et Al. The Nuclear Effector Of Wnt-Signaling, Tcf1, Functions As A T-Cell-Specific Tumor Suppressor For Development Of Lymphomas. Plos Biol. 2012;10(11):E1001430.

    合成参考文献


    参考文献:10.1046/j.1472-765x.2000.00677.x
    摘要:Davies CM, Apte SC. An evaluation of potential interferences in a fluorimetric assay for the rapid detection of thermotolerant coliforms in sewage. Lett Appl Microbiol. 2000 Feb;30(2):99–104. doi: 10.1046/j.1472-765x.2000.00677.x.
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