CAS: 6283-71-2; Dimethyl 2-Cyanosuccinate

该化合物是一种多用途乙酸衍生物,在2点方位上有一个环丙酸功能组,该化合物主要用作有机合成的中间体,特别是用于制备药品,农用化学品和特殊化学品.其双功能再活性,结合了酯类和硝基化合物,使其能用于循环,凝聚和核生殖替代反应.该化合物在普通有机溶剂中表现出良好的溶性,便于其在合成用途中处理.在标准条件下和定义明确的再活性特征下,其稳定性成为建造复杂分子框架的可靠建筑块.产品一般供应高度纯度,以确保在要求严格的合成工艺中保持一贯性能.

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上下游产品

CAS号96-34-4 氯乙酸甲酯 | CAS号105-34-0 氰乙酸甲酯 | CAS号67-56-1 甲醇 | CAS号105-39-5 氯乙酸乙酯 | CAS号105-56-6 氰乙酸乙酯 | CAS号52003-39-1 dimethyl 2-cyan...

合成工艺路线路线简述

  • 合成目标产物 2-Cyanobutanedioicacid,Dimethylester 主要起始原料 Methyl Chloroacetate And Methyl Cyanoacetate
  • (文献来源)合成步骤主要原料 Methyl Chloroacetate 和 Methyl Cyanoacetate
📜氯乙酸甲酯,氰乙酸甲酯置于sodium Methylate体系中,用86%的收率获得产物2-氰基丁二酸二甲酯
参考文献:Schank,Kurt; Lorig,Werner,Liebigs Annalen Der Chemie,1983,# 1,P. 112-136
标题:Schank,Kurt; Lorig,Werner,Liebigs Annalen Der Chemie,1983,# 1,P. 112-136

海关参考信息

专利信息


专利号:US-4442298-A
优先权日:1982-08-30
标 题:Chemical synthesis of ethylene/maleic anhydride dimer with phenylethyl end group
发明人:TOU JACOB S; SCHLEPPNIK ALFRED A
权利人:MONSANTO CO
摘要:A phenylethyl substituted dimer of ethylene and maleic anhydride, names 7-phenyloctane-(1,2),(5,6)-dianhydride, is chemically synthesized by n (a) alkylating alkyl 2,4-dihalobutyrate with alkyl 2-cyano-3-phenylbutyrate, n (b) alkylating the resulting halide condensation product with a carboxylate selected from the group consisting of trialkyl ethane-1,1,2-tricarboxylate and dimethyl cyanoethane-1,2-dicarboxylate, n (c) acid hydrolyzing the resulting tetra or pentaester accompanied by decarboxylating, and n (d) dehydrating the resulting tetra-acid to yield the desired phenylethyl substituted dimer of ethylene and maleic anhydride, n wherein the alkyls in the butyrate and carboxylate ester groups each contain from one to about four carbon atoms and halo is selected from the group consisting of bromo, chloro and iodo. n The dimer has anti-tumor and anti-viral properties and can be used in silver halide emulsions.

专利号:GB-2126228-A
优先权日:1982-08-30
标题 :Chemical synthesis of ema dimer with phenylethyl end group

专利号:US-7968584-B2
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER; PFIZER PROD INC
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2006134459-A1
优先权日:2005-06-15
标题 :Substituted arylpyrazoles
发明人:CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD; CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
摘要:This invention relates to a range of C4 substituted aryl pyrazoles of Formula (I) including those 1-arylpyrazoles in which the 4-position is substituted with an acyclic substituent, a cycloalkyl ring structure or heterocyclic ring structure and which compounds are optionally further substituted at the position a to the pyrazole ring, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7803832-B2
优先权日:2004-03-18
标题 :N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides
发明人:CRITCHER DOUGLAS JAMES; WALSHE NIGEL DEREK ARTHUR; LAURET CHRISTELLE
权利人:PFIZER; PFIZER PROD INC
摘要:The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R 1 -R 5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 4(322), 1952
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