CAS: 60710-39-6; 3-Bromo-4-Methylphenol

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CAS号7745-91-7 3-溴-4-甲基苯胺 | CAS号106-44-5 对甲酚 | CAS号36776-51-9 2,3,6-三溴-4-甲基苯酚 | CAS号7745-93-9 2-溴-4-硝基甲苯 | CAS号6627-55-0 2-溴-4-甲基苯酚 | CAS号39953-10-1 2,4,6-tribromo-... | CAS号2432-14-6 2,6-二溴-4-甲基苯酚 | CAS号7446-70-0 氯化铝 | CAS号108-86-1 溴苯 | CAS号106-41-2 对溴苯酚 | CAS号3168-59-0 2-甲基-5-甲氧基苯甲酸 | CAS号74317-85-4 2-溴-4-甲氧基-苯甲酸 | CAS号106-44-5 对甲酚 | CAS号6627-55-0 2-溴-4-甲基苯酚 | CAS号36942-56-0 3-溴-4-甲基苯甲醚 | CAS号164513-48-8 (3-溴-4-甲基苯氧基)(叔...

2-溴-4-硝基甲苯置于盐酸,Tin,硫酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 3-溴-4-甲基苯酚
参考文献:Electronic Effects Of Ring Substituents On Triplet Benzylic Biradicals
标题:Electronic Effects Of Ring Substituents On Triplet Benzylic Biradicals
摘要:Uv Irradiation Of Alpha-(O-Alkylphenyl)Acetophenones With A Methoxy Or Cyano Substituent Para To The O-Alkyl Group Of The Alpha-Aryl Ring Has Revealed That A Methoxy Group Slightly Increases The Stereoselectivity But Not The Quantum Yield Of Indanol Formation,Whereas A Cyano Group Greatly Lowers Both Diastereoselectivity And Quantum Efficiency,Confirming The Likelihood That Hydrogen-Bonding Of The Hydroxy Group To The Alpha-Phenyl Ring Plays An Important Role In The Cyclization Of The Photogenerated Triplet 1,5-Biradical Intermediates.
DOI:10.1021/ol0528383

专利信息

专利号:US-6476248-B1
优先权日:1998-12-18
标题:Hydroxythiol grignard reaction synthesis
发明人：RYCKMAN DAVID; ZHANG MINGBAO; CHEN GUOHUA
权利人:HONEYWELL INT INC
摘要:A method for the preparation of hydroxythiol compounds by reacting a hydroxyl-protected halide compound having the structure: n n n X—R—OPg n n n with magnesium in a Grignard-suitable solvent to form a hydroxyl-protected magnesium halide compound, wherein R is selected from substituted or unsubstituted aliphatic radicals, substituted or unsubstituted cyclic aliphatic radicals, substituted or unsubstituted aromatic radicals, substituted or unsubstituted araliphatic radicals and substituted or unsubstituted heterocyclic radicals; Pg is a protecting group; and X is selected from the group consisting of F, Cl, Br and I; then reacting said hydroxyl-protected magnesium halide compound with sulfur in the Grignard-suitable solvent to form a hydroxyl-protected thiomagnesium halide compound; and hydrolyzing the protected hydroxyl group to form a hydroxythiomagnesium halide compound and converting the thiomagnesium halide to a thiol; wherein the protecting group is selected so that species formed by the de-protection of the protecting group are inert toward thiols, or the method further includes the step of removing the protecting group species formed by de-protection of the hydroxyl group from the reaction mixture before converting the thiomagnesium halide to a thiol.

专利号:CA-3170288-A1
优先权日:2020-03-04
标题:Synthesis of novel ep4 antagonist and use in cancer and inflammation

专利号:EP-4116291-A1
优先权日:2020-03-04
标题:Synthesis of novel ep4 antagonist and use in cancers and inflammations

专利号:US-2023125494-A1
优先权日:2020-03-04
标题 :Synthesis of novel ep4 antagonist and use in cancer and inflammation

专利号:CN-113354585-A
优先权日:2020-03-04
标 题:Synthesis of novel EP4 antagonists and their use in cancer and inflammation

专利号:US-11434253-B2
优先权日:2017-12-14
标题 :Enantiopure terphenyls with two ortho-atropisomeric axes
发明人：DHERBASSY QUENTIN; WENCEL-DELORD JOANNA; COLOBERT FRANÇOISE; HEDOUIN GASPARD
权利人:UNIV STRASBOURG; CENTRE NAT RECH SCIENT
摘要:Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I): their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base and as generator, with metal, of isolable chiral metallic complexes for applications in asymmetric catalysis and others.