CAS: 575-36-0; N-(Naphthalen-1-yl)Acetamide

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diazomethane methanol diethyl ether 1-(diacetylamino)naphthalene1-(acetylamino)-4-bromonaphthalene (3-fluoro-phenyl)-naphthalen-1-yl-amine N-[4-(4-nitro-phenylazo)-[1]naphthyl]-acetamideN-[4-(4-nitro-phenylazo)-[1]naphthyl]-acetamide 4-nitro-1-naphthol

📜1-叠氮基萘置于盐酸体系中,用 氯仿 作为反应溶剂,化学反应 122.0H,反应生成 N-乙酰-1-萘胺
参考文献:1-芳基-1,2,3-三唑的光解; 通过1 H-叠氮基重排
标题:1-芳基-1,2,3-三唑的光解; 通过1 H-叠氮基重排
摘要:一系列1-(1-萘基)-1,2,3-三唑,(2)-(5)和1-(2-甲基-1-萘基)-1,2,3的制备和光解描述了在三唑环中带有和不带有吸电子基团(co 2 R,Conh 2,Cn,Cho,Coph)的-三唑(6)-(9).在第一个系列,三唑(3)具有两个吸电子基团,和三唑(4在c-4)与一个这样的基团,主要是得到[预期苯并的非常好的收率克]吲哚(10)和(11分别) .在c-5带有吸电子基团的三唑(5)也可反应生成苯并[g]吲哚,但是这些现在是预期的(12)和重排的吲哚(11)的混合物.1-苯基三唑(21)和(22)的光解遵循相同的模式,在c-5处具有吸电子基团的那些[(22)]重排,得到吲哚(23)和(24)的混合物.这是由一种机制(方案3)解释的,其中不稳定的卡宾中间体(13)通过1 H-叠氮基(14)重排为更好的卡宾(15).),与其直接环化竞争.这为抗芳香族1 H-叠氮基作为光化学反
DOI:10.1039/p19870000413

专利信息

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002165398-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.

专利号:EP-0043446-A1
优先权日:1980-07-04
标 题 :Intermediates of 13-thia-prostaglandin, their preparation and application to the synthesis of 13-thia-prostaglandin derivatives

专利号:US-2008176857-A1
优先权日:2005-03-25
标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2017156194-A1
优先权日:2016-03-08
标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
发明人：PUERTA DAVID T; COHEN SETH M; CREDILLE CY V
权利人:UNIV CALIFORNIA; PUERTA DAVID T
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-9079869-B2
优先权日:2009-03-02
标题:Chiral disulfonimides
发明人：LIST BENJAMIN; LAY FRANK; GARCIA GARCIA PILAR
权利人:LIST BENJAMIN; LAY FRANK; GARCIA GARCIA PILAR; STUDIENGESELLSCHAFT KOHLE MBH
摘要:Chiral disulfonimides having the formula I to III, n nwherein at least one of the groups A and B in the compound of formula I, C and D of the compound in formula II, and E and F of the compound in formula III is a chiral group, or E and F together form a chiral backbone,n X is C, Si, O, N or S, and n is 0, 1, 2, 3, 4, 5 or 6, where n is >1 only if X is C, and G is as defined herein, and to the organic salts, metal salts and metal complexes thereof, are suited as NMR shift reagents and as reagents for racemate splitting, and also as chiral Brønsted acid catalysts or chiral Lewis acid catalysts for activating ketones, aldehydes and alkenes, and also as catalysts in the organic synthesis.